3p1a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:00, 1 November 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3p1a is ON HOLD
+
==Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)==
-
 
+
<StructureSection load='3p1a' size='340' side='right'caption='[[3p1a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
Authors: Chaikuad, A., Eswaran, J., Fedorov, O., Cooper, C., Kroeler, T., Vollmar, M., Krojer, T., Berridge, G., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3p1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P1A FirstGlance]. <br>
-
Description: Structure of human Membrane-associated Tyrosine-and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:32:51 2010''
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [https://pdbe.org/3p1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [https://www.ebi.ac.uk/pdbsum/3p1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p1a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Berridge G]]
 +
[[Category: Bountra C]]
 +
[[Category: Chaikuad A]]
 +
[[Category: Cooper CDO]]
 +
[[Category: Edwards AM]]
 +
[[Category: Eswaran J]]
 +
[[Category: Fedorov O]]
 +
[[Category: Knapp S]]
 +
[[Category: Kroeler T]]
 +
[[Category: Krojer T]]
 +
[[Category: Muniz JRC]]
 +
[[Category: Pike ACW]]
 +
[[Category: Vollmar M]]
 +
[[Category: Weigelt J]]
 +
[[Category: Von Delft F]]

Current revision

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

PDB ID 3p1a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p1a"
Personal tools