3p23
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p23 is ON HOLD until Paper Publication Authors: Ali, M.M.U., Pearl, L.H. Description: Crystal structure of the Human kinase and RNase domains in c...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Human kinase and RNase domains in complex with ADP== | |
| + | <StructureSection load='3p23' size='340' side='right'caption='[[3p23]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P23 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p23 OCA], [https://pdbe.org/3p23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p23 RCSB], [https://www.ebi.ac.uk/pdbsum/3p23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p23 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0] | ||
| - | + | ==See Also== | |
| - | + | *[[Ire1|Ire1]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ali MMU]] | ||
| + | [[Category: Pearl LH]] | ||
Current revision
Crystal structure of the Human kinase and RNase domains in complex with ADP
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