This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3p3f
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p3f is ON HOLD Authors: Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y. Description: Crystal structure of the F36A mutant of the ...) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK== | |
| + | <StructureSection load='3p3f' size='340' side='right'caption='[[3p3f]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p3f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3f OCA], [https://pdbe.org/3p3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3f RCSB], [https://www.ebi.ac.uk/pdbsum/3p3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces cattleya]] | ||
| + | [[Category: Chang MCY]] | ||
| + | [[Category: Coyle SM]] | ||
| + | [[Category: Doudna JA]] | ||
| + | [[Category: Jinek M]] | ||
| + | [[Category: Weeks AM]] | ||
Current revision
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK
| |||||||||||
