3p3w
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p3w is ON HOLD Authors: Rossmann, M.R., Sukumaran, M., Greger, I.H. Description: Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A res...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A resolution== | |
| + | <StructureSection load='3p3w' size='340' side='right'caption='[[3p3w]], [[Resolution|resolution]] 4.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p3w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3W FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3w OCA], [https://pdbe.org/3p3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3w RCSB], [https://www.ebi.ac.uk/pdbsum/3p3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Greger IH]] | ||
| + | [[Category: Rossmann M]] | ||
| + | [[Category: Sukumaran M]] | ||
Current revision
Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A resolution
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