3p45
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p45 is ON HOLD Authors: Mueller, I., Lamers, M.B.A.C., Ritchie, A.J., Dominguez, C., Munoz, I., Maillard, M., Kiselyov, A. Description: Crystal st...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of apo-caspase-6 at physiological pH== | |
| + | <StructureSection load='3p45' size='340' side='right'caption='[[3p45]], [[Resolution|resolution]] 2.53Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p45]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P45 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p45 OCA], [https://pdbe.org/3p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p45 RCSB], [https://www.ebi.ac.uk/pdbsum/3p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p45 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | ||
| - | + | ==See Also== | |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dominguez C]] | ||
| + | [[Category: Kiselyov A]] | ||
| + | [[Category: Lamers MBAC]] | ||
| + | [[Category: Maillard M]] | ||
| + | [[Category: Mueller I]] | ||
| + | [[Category: Munoz I]] | ||
| + | [[Category: Ritchie AJ]] | ||
Current revision
Crystal structure of apo-caspase-6 at physiological pH
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