2l0i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:09, 21 November 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2l0i.png|left|200px]]
 
-
<!--
+
==Solution structure of Rtt103 CTD-interacting domain bound to a Ser2 phosphorylated CTD peptide==
-
The line below this paragraph, containing "STRUCTURE_2l0i", creates the "Structure Box" on the page.
+
<StructureSection load='2l0i' size='340' side='right'caption='[[2l0i]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2l0i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0I FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-
{{STRUCTURE_2l0i| PDB=2l0i | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0i OCA], [https://pdbe.org/2l0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0i RCSB], [https://www.ebi.ac.uk/pdbsum/2l0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0i ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0i_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0i ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Phosphorylation of the C-terminal domain (CTD) of RNA polymerase II controls the co-transcriptional assembly of RNA processing and transcription factors. Recruitment relies on conserved CTD-interacting domains (CIDs) that recognize different CTD phosphoisoforms during the transcription cycle, but the molecular basis for their specificity remains unclear. We show that the CIDs of two transcription termination factors, Rtt103 and Pcf11, achieve high affinity and specificity both by specifically recognizing the phosphorylated CTD and by cooperatively binding to neighboring CTD repeats. Single-residue mutations at the protein-protein interface abolish cooperativity and affect recruitment at the 3' end processing site in vivo. We suggest that this cooperativity provides a signal-response mechanism to ensure that its action is confined only to proper polyadenylation sites where Ser2 phosphorylation density is highest.
-
===Solution structure of Rtt103 CTD-interacting domain bound to a Ser2 phosphorylated CTD peptide===
+
Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain.,Lunde BM, Reichow SL, Kim M, Suh H, Leeper TC, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G Nat Struct Mol Biol. 2010 Oct;17(10):1195-201. Epub 2010 Sep 5. PMID:20818393<ref>PMID:20818393</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2l0i" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20818393}}, adds the Publication Abstract to the page
+
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20818393 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20818393}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2L0I is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0I OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20818393</ref><references group="xtra"/>
+
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Buratowski, S.]]
+
[[Category: Buratowski S]]
-
[[Category: Kim, M.]]
+
[[Category: Kim M]]
-
[[Category: Leeper, T C.]]
+
[[Category: Leeper TC]]
-
[[Category: Lunde, B M.]]
+
[[Category: Lunde BM]]
-
[[Category: Meinhart, A.]]
+
[[Category: Meinhart A]]
-
[[Category: Mutschler, H.]]
+
[[Category: Mutschler H]]
-
[[Category: Reichow, S L.]]
+
[[Category: Reichow SL]]
-
[[Category: Suh, H.]]
+
[[Category: Suh H]]
-
[[Category: Varani, G.]]
+
[[Category: Varani G]]
-
[[Category: Yang, F.]]
+
[[Category: Yang F]]
-
[[Category: 3' end processing]]
+
-
[[Category: Transcription]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:08:31 2010''
+

Current revision

Solution structure of Rtt103 CTD-interacting domain bound to a Ser2 phosphorylated CTD peptide

PDB ID 2l0i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l0i"
Personal tools