3p8c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 3p8c is ON HOLD Authors: Rosen, M Description: Structure and Control of the Actin Regulatory WAVE Complex ''Page seeded by [http://oca.weizmann.ac...)
Current revision (10:39, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3p8c is ON HOLD
+
==Structure and Control of the Actin Regulatory WAVE Complex==
 +
<StructureSection load='3p8c' size='340' side='right'caption='[[3p8c]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3p8c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8C FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8c OCA], [https://pdbe.org/3p8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8c RCSB], [https://www.ebi.ac.uk/pdbsum/3p8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8c ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Angelman syndrome.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
-
Authors: Rosen, M
+
==See Also==
-
 
+
*[[Wiskott-Aldrich syndrome protein|Wiskott-Aldrich syndrome protein]]
-
Description: Structure and Control of the Actin Regulatory WAVE Complex
+
== References ==
-
 
+
<references/>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:23:26 2010''
+
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Billadeau DD]]
 +
[[Category: Borek D]]
 +
[[Category: Chen Z]]
 +
[[Category: Gomez TS]]
 +
[[Category: Ismail AM]]
 +
[[Category: Metlagel Z]]
 +
[[Category: Otwinowski Z]]
 +
[[Category: Padrick SB]]
 +
[[Category: Rosen MK]]
 +
[[Category: Umetani J]]

Current revision

Structure and Control of the Actin Regulatory WAVE Complex

PDB ID 3p8c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p8c"
Personal tools