3n96

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{{Seed}}
 
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[[Image:3n96.jpg|left|200px]]
 
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==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1==
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The line below this paragraph, containing "STRUCTURE_3n96", creates the "Structure Box" on the page.
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<StructureSection load='3n96' size='340' side='right'caption='[[3n96]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N96 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_3n96| PDB=3n96 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n96 OCA], [https://pdbe.org/3n96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n96 RCSB], [https://www.ebi.ac.uk/pdbsum/3n96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n96 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1===
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
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__TOC__
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==About this Structure==
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</StructureSection>
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3N96 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N96 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pal, K.]]
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[[Category: Large Structures]]
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[[Category: Pioszak, A A.]]
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[[Category: Pal K]]
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[[Category: Swaminathan, K.]]
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[[Category: Pioszak AA]]
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[[Category: Xu, H E.]]
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[[Category: Swaminathan K]]
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[[Category: Class b-gpcr]]
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[[Category: Xu HE]]
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[[Category: Crfr2 alpha extracellular domain]]
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[[Category: Extracellular domain]]
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[[Category: Hormone]]
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[[Category: Membrane protein]]
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[[Category: Neuropeptide]]
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[[Category: Selectivity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:37:51 2010''
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Current revision

Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1

PDB ID 3n96

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