Sandbox caroldavila

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=[Image:Opening 1igt.png|450px|left|thumb| Intact Immunoglobulin, [[1igt]]]]
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{{STRUCTURE_1hzh| right| PDB=1hzh | SCENE=Antibody/1hzh_starting_scene/3 |CAPTION= Structura IGG B12 uman: o mostra a unui posibil vaccin pentru HIV, [[1hzh]] }}
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{{STRUCTURE_1hzh| right| PDB=1hzh | SCENE=Antibody/1hzh_starting_scene/3 |CAPTION= Structura IGG B12 uman: o monstra pentru un potential vaccin HIV, [[1hzh]] }}
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'''Anticorpii''', deasemenea cunoscuti ca Imunoglobuline (Ig) sunt gama=globuline de natura proteica, gasite in principal in sangele vertebratelor. Acestea [[glicoproteine]] reprezinta o componenta critica a sistemului imun cand gazda nu reuseste sa activeze calea alternativa a complementului sau celule cu capacitate de fagocitare ca raspuns la organismulele invadatoare sau alte [http://en.wikipedia.org/wiki/Antigen antigene]. Aceasta incredibila specificitate cu ajutorul carora IG leaga antigenul este bazat pe complementaritate structurala intre antigen si anticorp, pe baza lanturilor <scene name='Antibody/1hzh_heavy_chains/1'>grele </scene>si <scene name='Antibody/1hzh_light_chains/1'> usoare </scene>. Aceasta specificitate este cea care a facut din <scene name='Antibody/1hzh_starting_scene/3'>anticorpi</scene> o componenta criticala a medicinei si cercetarii.
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'''Antibodies''', also known as Immunoglobulins (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates. These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research.
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[[Image:230px-B cell activation2.png|270px|left|thumb| Production of Antibodies by Plasma Cells]]
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==Structure of the Immunoglobulin==
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{{STRUCTURE_1igt| right| |size=400| PDB=1igt | Size=400px| SCENE=Antibody/1igt_starting_scene/3 |CAPTION= Refined Structure of an Intact IgG2a Monoclonal Antibody, [[1igt]] }}
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The basic functional unit of an antibody is an immunoglobulin monomer, but antibodies secreted from plasma cells are typically dimeric with occasional higher order structures. Typical secreted antibodies have a basic four-peptide structure of two identical <scene name='Antibody/1igt_heavy_chains/1'>heavy chains </scene>and two identical <scene name='Antibody/1igt_light_chains/1'>light chains</scene> joined together by interchain <scene name='Antibody/1igt_disulfide_bonds/2'>disulfide bonds</scene>, forming a “Y” shaped molecule. The disulfide bonds are positioned within a flexible region called the <scene name='Antibody/1igt_hinge_region/1'>hinge region</scene>, which seperates the lobes of the antibody from one another and provides ample flexibility to bind antigens effectively. <ref name="Roit" /> Each domain (2 heavy and 2 light) contain between 70-110 amino acids and are classified into different categories according to size and function. <ref>PMID:10545762</ref> Both domains, heavy and light, contain variable and constant regions that are crucial to antibody function. <ref>PMID:107164</ref>
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Current revision

PDB ID 1hzh

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Structura IGG B12 uman: o mostra a unui posibil vaccin pentru HIV, 1hzh
Ligands: , , , ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Anticorpii, deasemenea cunoscuti ca Imunoglobuline (Ig) sunt gama=globuline de natura proteica, gasite in principal in sangele vertebratelor. Acestea glicoproteine reprezinta o componenta critica a sistemului imun cand gazda nu reuseste sa activeze calea alternativa a complementului sau celule cu capacitate de fagocitare ca raspuns la organismulele invadatoare sau alte antigene. Aceasta incredibila specificitate cu ajutorul carora IG leaga antigenul este bazat pe complementaritate structurala intre antigen si anticorp, pe baza lanturilor si . Aceasta specificitate este cea care a facut din o componenta criticala a medicinei si cercetarii.

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