3ki5
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:3ki5.jpg|left|200px]] | ||
| - | < | + | ==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-M== |
| - | + | <StructureSection load='3ki5' size='340' side='right'caption='[[3ki5]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ki5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9M:N-(6-OXO-5,6-DIHYDROBENZO[C][1,5]NAPHTHYRIDIN-2-YL)-2-(4-PYRROLIDIN-1-YLPIPERIDIN-1-YL)ACETAMIDE'>G9M</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki5 OCA], [https://pdbe.org/3ki5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki5 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Exotoxin 3D structures|Exotoxin 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
| - | [[Category: Edwards | + | [[Category: Edwards PR]] |
| - | [[Category: Jorgensen | + | [[Category: Jorgensen R]] |
| - | [[Category: Merrill | + | [[Category: Merrill AR]] |
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Current revision
Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-M
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