3ln0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (02:05, 21 November 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3ln0.jpg|left|200px]]
 
-
<!--
+
==Structure of compound 5c-S bound at the active site of COX-2==
-
The line below this paragraph, containing "STRUCTURE_3ln0", creates the "Structure Box" on the page.
+
<StructureSection load='3ln0' size='340' side='right'caption='[[3ln0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ln0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LN0 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52B:(2S)-6,8-DICHLORO-2-(TRIFLUOROMETHYL)-2H-CHROMENE-3-CARBOXYLIC+ACID'>52B</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_3ln0| PDB=3ln0 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ln0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ln0 OCA], [https://pdbe.org/3ln0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ln0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ln0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ln0 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In this Letter, we provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors. During the course of our structure-based drug design efforts, we discovered two distinct binding modes within the COX-2 active site for differently substituted members of this class. The challenge of a undesirably long human half-life for the first clinical candidate 1t(1/2)=360h was addressed by multiple strategies, leading to the discovery of 29b-(S) (SC-75416) with t(1/2)=34h.
-
===Structure of compound 5c-S bound at the active site of COX-2===
+
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life.,Wang JL, Limburg D, Graneto MJ, Springer J, Hamper JR, Liao S, Pawlitz JL, Kurumbail RG, Maziasz T, Talley JJ, Kiefer JR, Carter J Bioorg Med Chem Lett. 2010 Jul 24. PMID:20709553<ref>PMID:20709553</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3ln0" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20709553}}, adds the Publication Abstract to the page
+
*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20709553 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20709553}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3LN0 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LN0 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20709553</ref><references group="xtra"/>
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Prostaglandin-endoperoxide synthase]]
+
[[Category: Kiefer JR]]
-
[[Category: Kiefer, J R.]]
+
[[Category: Kurumbail RG]]
-
[[Category: Kurumbail, R G.]]
+
[[Category: Pawlitz JL]]
-
[[Category: Pawlitz, J L.]]
+
[[Category: Stallings WC]]
-
[[Category: Stallings, W C.]]
+
-
[[Category: Cox-2]]
+
-
[[Category: Cox2]]
+
-
[[Category: Cyclooxygenase-2]]
+
-
[[Category: Dioxygenase]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Fatty acid biosynthesis]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Heme]]
+
-
[[Category: Iron]]
+
-
[[Category: Lipid synthesis]]
+
-
[[Category: Membrane]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Microsome]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Peroxidase]]
+
-
[[Category: Pgh2s-2]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Prostaglandin biosynthesis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:10:11 2010''
+

Current revision

Structure of compound 5c-S bound at the active site of COX-2

PDB ID 3ln0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ln0"
Personal tools