3lu6

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{{Seed}}
 
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[[Image:3lu6.jpg|left|200px]]
 
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==Human serum albumin in complex with compound 1==
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The line below this paragraph, containing "STRUCTURE_3lu6", creates the "Structure Box" on the page.
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<StructureSection load='3lu6' size='340' side='right'caption='[[3lu6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lu6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LU6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMX:[(1R,2R)-2-{[(5-FLUORO-1H-INDOL-2-YL)CARBONYL]AMINO}-2,3-DIHYDRO-1H-INDEN-1-YL]ACETIC+ACID'>IMX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3lu7|3lu7]], [[3lu8|3lu8]]</div></td></tr>
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{{STRUCTURE_3lu6| PDB=3lu6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu6 OCA], [https://pdbe.org/3lu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lu6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been used to assign a primary binding site for these compounds in the presence and absence of fatty acids. The crystal structures have also been solved for three compounds: a matched pair of carboxylic acids whose binding strength to HSA unexpectedly decreased as the lipophilicity increased; and a highly bound sulphonamide that appeared not to displace the probes in the displacement assay. The crystallography results support the findings from the fluorescence displacement assay. The results indicate that drug binding to subdomain IB might also be important location for certain compounds.
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===Human serum albumin in complex with compound 1===
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A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.,Buttar D, Colclough N, Gerhardt S, MacFaul PA, Phillips SD, Plowright A, Whittamore P, Tam K, Maskos K, Steinbacher S, Steuber H Bioorg Med Chem. 2010 Nov 1;18(21):7486-96. Epub 2010 Sep 24. PMID:20869876<ref>PMID:20869876</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3lu6" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20869876}}, adds the Publication Abstract to the page
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*[[Albumin 3D structures|Albumin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20869876 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20869876}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3LU6 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU6 OCA].
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==Reference==
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<ref group="xtra">PMID:20869876</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Buttar, D.]]
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[[Category: Large Structures]]
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[[Category: Colclough, N.]]
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[[Category: Buttar, D]]
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[[Category: Gerhardt, S.]]
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[[Category: Colclough, N]]
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[[Category: MacFaul, P A.]]
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[[Category: Gerhardt, S]]
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[[Category: Maskos, K.]]
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[[Category: MacFaul, P A]]
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[[Category: Phillips, S D.]]
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[[Category: Maskos, K]]
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[[Category: Plowright, A.]]
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[[Category: Phillips, S D]]
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[[Category: Steinbacher, S.]]
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[[Category: Plowright, A]]
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[[Category: Steuber, H.]]
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[[Category: Steinbacher, S]]
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[[Category: Tam, K.]]
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[[Category: Steuber, H]]
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[[Category: Whittamore, P.]]
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[[Category: Tam, K]]
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[[Category: Whittamore, P]]
[[Category: Astrazeneca]]
[[Category: Astrazeneca]]
[[Category: Binding site]]
[[Category: Binding site]]
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[[Category: Serum albumin]]
[[Category: Serum albumin]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:10:17 2010''
 

Current revision

Human serum albumin in complex with compound 1

PDB ID 3lu6

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