User:Eran Hodis/Sandbox5
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| - | TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular reaction<ref>http://en.wikipedia.org/wiki/Oxidation_reduction | + | TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular reaction<ref>http://en.wikipedia.org/wiki/Oxidation_reduction</ref>. This isomerization of a ketose to an aldose proceeds through an ''cis''-enediol(ate) intermediate. This isomerization proceeds without any cofactors and the enzyme confers a 10<sup>9</sup> rate enhancement relative to the nonenzymatic reaction involving a chemical base (acetate ion).<ref>PMID:2043623</ref> |
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==References== | ==References== | ||
<references/> | <references/> | ||
Current revision
TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular reaction[1]. This isomerization of a ketose to an aldose proceeds through an cis-enediol(ate) intermediate. This isomerization proceeds without any cofactors and the enzyme confers a 109 rate enhancement relative to the nonenzymatic reaction involving a chemical base (acetate ion).[2]
References
- ↑ http://en.wikipedia.org/wiki/Oxidation_reduction
- ↑ Davenport RC, Bash PA, Seaton BA, Karplus M, Petsko GA, Ringe D. Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. Biochemistry. 1991 Jun 18;30(24):5821-6. PMID:2043623
