2bjo
From Proteopedia
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| - | [[Image:2bjo.gif|left|200px]]<br /><applet load="2bjo" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2bjo, resolution 2.101Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS'''<br /> | ||
| - | == | + | ==Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis== |
| - | The crystal structure of the fully oxidized form of the Bacillus subtilis | + | <StructureSection load='2bjo' size='340' side='right'caption='[[2bjo]], [[Resolution|resolution]] 2.10Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjo OCA], [https://pdbe.org/2bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bjo RCSB], [https://www.ebi.ac.uk/pdbsum/2bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bjo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OHRB_BACSU OHRB_BACSU] Involved in organic hydroperoxide resistance.<ref>PMID:11418552</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/2bjo_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bjo ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the fully oxidized form of the Bacillus subtilis organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A resolution. The electron density reveals an intact catalytic disulfide bond (Cys55-Cys119) in each of the two molecules, which are intertwined into a canonical obligate dimer. However, the stereochemistry of the disulfides is unorthodox and strained, suggesting that they are sensitive to reducing agents. A deep solvent-accessible gorge reaching Cys55 may represent the access route for the reductant. | ||
| - | + | Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state.,Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074<ref>PMID:18084074</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2bjo" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Organic hydroperoxide resistance protein|Organic hydroperoxide resistance protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus subtilis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bielnicki J]] | ||
| + | [[Category: Cooper DR]] | ||
| + | [[Category: Derewenda ZS]] | ||
| + | [[Category: Devedjiev Y]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Surendranath Y]] | ||
Current revision
Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis
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