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< User:Eran Hodis(Difference between revisions)
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| - | ==Your Heading Here (maybe something like 'Structure')==
| + | <molshow refresh="50" size=300> |
| - | <StructureSection load='1dq8' size='400' structureSide='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])'> | + | |
| - | ===General Structure===
| + | |
| - | There are two distinct classes of HMGRs, class I, which is only found in eukaryotes and are membrane bound and class II, which is found in prokaryotes and are soluble. <ref>PMID:11349148</ref> HMGR contains 8 transmembrane domains that have yet to be successfully crystallized, which anchor the protein to the membrane of the endoplasmic reticulum. <ref name="Roitelman"/> The catalytic portion of human HMGR forms a tetramer, with the individual monomers winding around each other. <ref name="Roitelman">PMID:1374417</ref> Within the tetramer, the monomers are arranged into <scene name='HMG-CoA_Reductase/1dq8_2_dimers/3'>two dimers</scene>, each of which contains <scene name='HMG-CoA_Reductase/1dq8_2_active_sites/2'>two active sites </scene>which are formed by residues form both monomers. Each monomer contains <scene name='HMG-CoA_Reductase/1dq8_star3_domains/2'>three domains </scene>, the <scene name='HMG-CoA_Reductase/1dq8_n_domain/2'>N-domain</scene>, the <scene name='HMG-CoA_Reductase/1dq8_l_domain/1'>L-Domain</scene>, and the <scene name='HMG-CoA_Reductase/1dq8_s_domain/1'>S-Domain</scene>. The L-domain is unique to HMGRs while the S-domain, which forms the binding site for NADP, resembles that of [[ferredoxin]]. The S and L domains are connected by a <scene name='HMG-CoA_Reductase/1dq8_cis_loop/6'>“cis-loop”</scene> which is essential for the HMG-binding site. <ref name="Roitelman"/> Salt bridges between residues R641 and E782 as well as <scene name='HMG-CoA_Reductase/1dq8_cis_loop/4'>hydrogen bonds</scene> between E700 and E700 on neighboring monomers compliment the largely hydrophobic dimer-dimer interface. <ref name="Roitelman"/>
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| - | </StructureSection>
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| - | <Structure load='1aoi' size='200' frame='true' align='right' caption='' />
| + | scene =User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1 |
| | + | caption=isolated Heme |
| | | | |
| | + | scene = User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Sickle_hemoglobin_chain/1 |
| | + | caption = aggregate |
| | | | |
| - | {{Clear}}
| + | scene = Journal:JBIC:3/Motif_good/5 |
| | + | caption = Here a long long explanation on what we could see |
| | + | from a closer look to the molecule |
| | + | if it were possible to make part of it transparent. |
| | | | |
| - | ==Nucleosome Structure==
| + | </molshow> |
| - | <table style="width: 100%;"> | + | |
| - | <tr>
| + | |
| - | <td>
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| - | <applet load='1aoi' size='300' frame='true' align='right' caption='' />
| + | |
| - | </td>
| + | |
| - | <td>
| + | |
| - | <div style="background-color: #ffe8e8;overflow: auto;height: 300px;width: 100%;">
| + | |
| - | {{:User:Eran Hodis/Sandbox6}}
| + | |
| - | </div>
| + | |
| - | </td>
| + | |
| - | </tr>
| + | |
| - | </table>
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| - | | + | |
| - | ==References==
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| - | <references/>
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Current revision
<molshow refresh="50" size=300>
scene =User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1
caption=isolated Heme
scene = User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Sickle_hemoglobin_chain/1
caption = aggregate
scene = Journal:JBIC:3/Motif_good/5
caption = Here a long long explanation on what we could see
from a closer look to the molecule
if it were possible to make part of it transparent.
</molshow>
