2xvc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2xvc is ON HOLD Authors: Samson, R.Y., Obita, T., Hodgson, B., Shaw, M., Chong, P.L.G., Williams, R.L., Bell, S.D. Description: Molecular and struc...) |
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- | '''Unreleased structure''' | ||
- | + | ==Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division== | |
+ | <StructureSection load='2xvc' size='340' side='right'caption='[[2xvc]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[2xvc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVC FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvc OCA], [https://pdbe.org/2xvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvc RCSB], [https://www.ebi.ac.uk/pdbsum/2xvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvc ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/Q97ZJ6_SACS2 Q97ZJ6_SACS2] | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Members of the crenarchaeal kingdom, such as Sulfolobus, divide by binary fission yet lack genes for the otherwise near-ubiquitous tubulin and actin superfamilies of cytoskeletal proteins. Recent work has established that Sulfolobus homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in Sulfolobus cell division. In eukaryotes, several pathways recruit ESCRT-III proteins to their sites of action. However, the positioning determinants for archaeal ESCRT-III are not known. Here, we identify a protein, CdvA, that is responsible for recruiting Sulfolobus ESCRT-III to membranes. Overexpression of the isolated ESCRT-III domain that interacts with CdvA results in the generation of nucleoid-free cells. Furthermore, CdvA and ESCRT-III synergize to deform archaeal membranes in vitro. The structure of the CdvA/ESCRT-III interface gives insight into the evolution of the more complex and modular eukaryotic ESCRT complex. | ||
- | + | Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division.,Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD Mol Cell. 2011 Jan 21;41(2):186-96. PMID:21255729<ref>PMID:21255729</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | <div class="pdbe-citations 2xvc" style="background-color:#fffaf0;"></div> | |
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Saccharolobus solfataricus]] | ||
+ | [[Category: Bell SD]] | ||
+ | [[Category: Chong PL]] | ||
+ | [[Category: Hodgson B]] | ||
+ | [[Category: Obita T]] | ||
+ | [[Category: Samson RY]] | ||
+ | [[Category: Shaw MK]] | ||
+ | [[Category: Williams RL]] |
Current revision
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division
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