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3ih7
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:3ih7.jpg|left|200px]] | ||
| - | + | ==Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA== | |
| - | + | <StructureSection load='3ih7' size='340' side='right'caption='[[3ih7]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | or the | + | <table><tr><td colspan='2'>[[3ih7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IH7 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ih7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ih7 OCA], [https://pdbe.org/3ih7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ih7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ih7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ih7 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||
| - | === | + | ==See Also== |
| - | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Crenshaw CM]] |
| - | [[Category: | + | [[Category: Kutchukian PS]] |
| - | [[Category: | + | [[Category: Oo KS]] |
| - | [[Category: | + | [[Category: Verdine GL]] |
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Current revision
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
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