3l35

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (02:03, 21 November 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3l35.jpg|left|200px]]
 
-
<!--
+
==PIE12 D-peptide against HIV entry==
-
The line below this paragraph, containing "STRUCTURE_3l35", creates the "Structure Box" on the page.
+
<StructureSection load='3l35' size='340' side='right'caption='[[3l35]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3l35]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L35 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=DGN:D-GLUTAMINE'>DGN</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
{{STRUCTURE_3l35| PDB=3l35 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l35 OCA], [https://pdbe.org/3l35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l35 RCSB], [https://www.ebi.ac.uk/pdbsum/3l35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l35 ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The HIV gp41 N-trimer pocket region is an ideal viral target because it is extracellular, highly conserved, and essential for viral entry. Here, we report on the design of a pocket-specific D-peptide, PIE12-trimer, that is extraordinarily elusive to resistance and characterize its inhibitory and structural properties. D-peptides (peptides composed of D-amino acids) are promising therapeutic agents due to their insensitivity to protease degradation. PIE12-trimer was designed using structure-guided mirror-image phage display and linker optimization and is the first D-peptide HIV entry inhibitor with the breadth and potency required for clinical use. PIE12-trimer has an ultrahigh affinity for the gp41 pocket, providing it with a reserve of binding energy (resistance capacitor) that yields a dramatically improved resistance profile compared to those of other fusion inhibitors. These results demonstrate that the gp41 pocket is an ideal drug target and establish PIE12-trimer as a leading anti-HIV antiviral candidate.
-
===PIE12 D-peptide against HIV entry===
+
Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance.,Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS J Virol. 2010 Nov;84(21):11235-44. Epub 2010 Aug 18. PMID:20719956<ref>PMID:20719956</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20719956}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3l35" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20719956 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20719956}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3L35 is a 6 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L35 OCA].
+
[[Category: Eckert DM]]
-
 
+
[[Category: Hill CP]]
-
==Reference==
+
[[Category: Kay MS]]
-
<ref group="xtra">PMID:20719956</ref><references group="xtra"/>
+
[[Category: Lie YS]]
-
[[Category: Eckert, D M.]]
+
[[Category: Paul S]]
-
[[Category: Hill, C P.]]
+
[[Category: Redman JS]]
-
[[Category: Kay, M S.]]
+
[[Category: Reeves JD]]
-
[[Category: Lie, Y S.]]
+
[[Category: Root MJ]]
-
[[Category: Paul, S.]]
+
[[Category: Weinstock MT]]
-
[[Category: Redman, J S.]]
+
[[Category: Welch BD]]
-
[[Category: Reeves, J D.]]
+
[[Category: Whitby FG]]
-
[[Category: Root, M J.]]
+
-
[[Category: Weinstock, M T.]]
+
-
[[Category: Welch, B D.]]
+
-
[[Category: Whitby, F G.]]
+
-
[[Category: Coiled-coil]]
+
-
[[Category: D-peptide inhibitor]]
+
-
[[Category: De novo protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:09:20 2010''
+

Current revision

PIE12 D-peptide against HIV entry

PDB ID 3l35

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3l35"
Personal tools