3p7g

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{{Seed}}
 
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[[Image:3p7g.jpg|left|200px]]
 
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==Structure of the human Langerin carbohydrate recognition domain in complex with mannose==
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The line below this paragraph, containing "STRUCTURE_3p7g", creates the "Structure Box" on the page.
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<StructureSection load='3p7g' size='340' side='right'caption='[[3p7g]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p7g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bc7 3bc7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P7G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3p7g| PDB=3p7g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p7g OCA], [https://pdbe.org/3p7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p7g RCSB], [https://www.ebi.ac.uk/pdbsum/3p7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p7g ProSAT]</span></td></tr>
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</table>
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===Structure of the human Langerin carbohydrate recognition domain in complex with mannose===
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== Disease ==
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[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 18061677 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_18061677}}
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</StructureSection>
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==About this Structure==
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3P7G is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bc7 3bc7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7G OCA].
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==Reference==
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<ref group="xtra">PMID:18061677</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Schiefner, A.]]
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[[Category: Large Structures]]
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[[Category: Skerra, A.]]
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[[Category: Schiefner A]]
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[[Category: C-type lectin]]
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[[Category: Skerra A]]
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[[Category: Calcium binding]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Cd207]]
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[[Category: Dc-sign]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Langerhans cell]]
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[[Category: Langerin]]
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[[Category: Membrane protein]]
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[[Category: Sugar binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:15:29 2010''
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Current revision

Structure of the human Langerin carbohydrate recognition domain in complex with mannose

PDB ID 3p7g

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