3pel

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==Structure of Greyhound Hemoglobin: Origin of High Oxygen Affinity==
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<StructureSection load='3pel' size='340' side='right'caption='[[3pel]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3n48 3n48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_3pel| PDB=3pel | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pel OCA], [https://pdbe.org/3pel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pel RCSB], [https://www.ebi.ac.uk/pdbsum/3pel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pel ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBA_CANLF HBA_CANLF] Involved in oxygen transport from the lung to the various peripheral tissues. Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.[UniProtKB:P01946]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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This study presents the crystal structure of Greyhound hemoglobin (GrHb) determined to 1.9 A resolution. GrHb was found to crystallize with an alpha(1)beta(1) dimer in the asymmetric unit and belongs to the R2 state. Oxygen-affinity measurements combined with the fact that GrHb crystallizes in the R2 state despite the high-salt conditions used for crystallization strongly indicate that GrHb can serve as a model high-oxygen-affinity hemoglobin (Hb) for higher mammals, especially humans. Structural analysis of GrHb and its comparison with the R2-state of human Hb revealed several regions that can potentially contribute to the high oxygen affinity of GrHb and serve to rationalize the additional stability of the R2-state of GrHb. A previously well studied hydrophobic cluster of bar-headed goose Hb near alpha119 was also incorporated in the comparison between GrHb and human Hb. Finally, a structural comparison with generic dog Hb and maned wolf Hb was conducted, revealing that in contrast to GrHb these structures belong to the R state of Hb and raising the intriguing possibility of an additional allosteric factor co-purifying with GrHb that can modulate its quaternary structure.
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===Structure of Greyhound Hemoglobin: Origin of High Oxygen Affinity===
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Structure of Greyhound hemoglobin: origin of high oxygen affinity.,Bhatt VS, Zaldivar-Lopez S, Harris DR, Couto CG, Wang PG, Palmer AF Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):395-402. Epub 2011, Apr 13. PMID:21543841<ref>PMID:21543841</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pel" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3PEL is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEL OCA].
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Bhatt, V S.]]
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[[Category: Large Structures]]
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[[Category: Couto, C G.]]
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[[Category: Bhatt VS]]
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[[Category: Harris, D R.]]
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[[Category: Couto CG]]
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[[Category: Palmer, A F.]]
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[[Category: Harris DR]]
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[[Category: Wang, P G.]]
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[[Category: Palmer AF]]
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[[Category: Zaldivar-Lopez, S.]]
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[[Category: Wang PG]]
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[[Category: Globin fold]]
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[[Category: Zaldivar-Lopez S]]
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[[Category: Heme binding]]
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[[Category: Oxygen transport]]
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[[Category: Oxygen/co2 transport]]
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[[Category: Red blood cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:17:05 2010''
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Current revision

Structure of Greyhound Hemoglobin: Origin of High Oxygen Affinity

PDB ID 3pel

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