3mnv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment== | |
| + | <StructureSection load='3mnv' size='340' side='right'caption='[[3mnv]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3mnv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnv OCA], [https://pdbe.org/3mnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnv RCSB], [https://www.ebi.ac.uk/pdbsum/3mnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8TCD0_HUMAN Q8TCD0_HUMAN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation. | ||
| - | + | Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.,Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF Nat Struct Mol Biol. 2010 Dec;17(12):1492-4. Epub 2010 Nov 14. PMID:21076400<ref>PMID:21076400</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3mnv" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Alam SM]] | ||
| + | [[Category: Dennison SM]] | ||
| + | [[Category: Haynes BF]] | ||
| + | [[Category: Kelsoe G]] | ||
| + | [[Category: Liao H-X]] | ||
| + | [[Category: Nicely NI]] | ||
Current revision
Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment
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Categories: Homo sapiens | Large Structures | Mus musculus | Alam SM | Dennison SM | Haynes BF | Kelsoe G | Liao H-X | Nicely NI
