3phn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3phn is ON HOLD Authors: Kurpiewska, K., Torrent, G., Ribo, M., Vilanova, M., Loch, J., Lewinski, K. Description: Crystal structure of wild-type on...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of wild-type onconase with resolution 1.46 A== | |
| - | + | <StructureSection load='3phn' size='340' side='right'caption='[[3phn]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3phn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | '' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phn OCA], [https://pdbe.org/3phn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phn RCSB], [https://www.ebi.ac.uk/pdbsum/3phn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lithobates pipiens]] | ||
| + | [[Category: Kurpiewska K]] | ||
| + | [[Category: Lewinski K]] | ||
| + | [[Category: Loch J]] | ||
| + | [[Category: Ribo M]] | ||
| + | [[Category: Torrent G]] | ||
| + | [[Category: Vilanova M]] | ||
Current revision
Crystal structure of wild-type onconase with resolution 1.46 A
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