2e3m
From Proteopedia
(Difference between revisions)
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2e3m.jpg|left|200px]]<br /><applet load="2e3m" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2e3m, resolution 2.20Å" /> | ||
| - | '''Crystal structure of CERT START domain'''<br /> | ||
| - | == | + | ==Crystal structure of CERT START domain== |
| - | + | <StructureSection load='2e3m' size='340' side='right'caption='[[2e3m]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2e3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3m OCA], [https://pdbe.org/2e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3m RCSB], [https://www.ebi.ac.uk/pdbsum/2e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3m_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3m ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hanada | + | [[Category: Hanada K]] |
| - | [[Category: Kato | + | [[Category: Kato R]] |
| - | [[Category: Kudo | + | [[Category: Kudo N]] |
| - | [[Category: Kumagai | + | [[Category: Kumagai K]] |
| - | [[Category: Nishijima | + | [[Category: Nishijima M]] |
| - | [[Category: Wakatsuki | + | [[Category: Wakatsuki S]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of CERT START domain
| |||||||||||
Categories: Homo sapiens | Large Structures | Hanada K | Kato R | Kudo N | Kumagai K | Nishijima M | Wakatsuki S
