3lgy

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{{Seed}}
 
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[[Image:3lgy.png|left|200px]]
 
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==R178A mutant of the DegS-deltaPDZ protease==
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The line below this paragraph, containing "STRUCTURE_3lgy", creates the "Structure Box" on the page.
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<StructureSection load='3lgy' size='340' side='right'caption='[[3lgy]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LGY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3lgy| PDB=3lgy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lgy OCA], [https://pdbe.org/3lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lgy RCSB], [https://www.ebi.ac.uk/pdbsum/3lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lgy ProSAT]</span></td></tr>
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</table>
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===R178A mutant of the DegS-deltaPDZ protease===
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== Function ==
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[https://www.uniprot.org/uniprot/DEGS_ECOLI DEGS_ECOLI] When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMPs) and then initiates RseA (anti sigma-E factor) degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by RseP. This cascade that ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly.<ref>PMID:12183369</ref> <ref>PMID:19695325</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_20739286}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20739286 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lg/3lgy_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20739286}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3LGY is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGY OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lgy ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:20739286</ref><references group="xtra"/>
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<references/>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Grant, R A.]]
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</StructureSection>
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[[Category: Sauer, R T.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Sohn, J.]]
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[[Category: Large Structures]]
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[[Category: Htra]]
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[[Category: Grant RA]]
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[[Category: Hydrolase]]
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[[Category: Sauer RT]]
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[[Category: Pdz omp]]
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[[Category: Sohn J]]
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[[Category: Protease]]
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[[Category: Serine protease]]
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[[Category: Stress-sensor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:55:26 2010''
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Current revision

R178A mutant of the DegS-deltaPDZ protease

PDB ID 3lgy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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