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Lamprey Variable Lymphocyte Receptor
From Proteopedia
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| - | [[Image: | + | [[Image:3g3a biol unitsurf.png|370px|left|thumb| Lamprey Variable Lymphocyte Receptor in complex with a protein antigen ([[3g3a]])]] |
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| - | {{ | + | {{Structure |
| + | |PDB= 3e6j |SIZE=350|SCENE=Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/3|CAPTION= Lamprey Variable Lymphocyte Receptor in complex with a trisaccharide antigen ([[3e6j]]), resolution 1.67Å (<scene name='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/3'>initial scene</scene>) | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6j OCA], [http://www.ebi.ac.uk/pdbsum/3e6j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3e6j RCSB]</span> | ||
| + | }} | ||
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===Crystal Structure of Variable Lymphocyte Receptor (VLR) RBC36 in Complex with H-trisaccharide=== | ===Crystal Structure of Variable Lymphocyte Receptor (VLR) RBC36 in Complex with H-trisaccharide=== | ||
| - | < | + | <scene name='Lamprey_Variable_Lymphocyte_Receptor/Ncrainbow/1'>N->C rainbow of the protein</scene> |
| - | + | <scene name='Lamprey_Variable_Lymphocyte_Receptor/Leucines_highlighted/1'>Leucines highlighed in cyan</scene> | |
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| - | ==About | + | ==About these Structures== |
| - | + | Lamprey [[Variable Lymphocyte Receptors|VLRs]] are members of the [[Leucine-rich repeat]] (LRR) family of diverse proteins. [[Variable Lymphocyte Receptors|Variable lymphocyte receptors]] are involved in the adaptative immune response.<br> | |
| + | [[3e6j]] is a single chain structure of sequence from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6J OCA]. | ||
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| + | [[3g3b]] is an 8 chain structure with sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3B OCA]. | ||
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| + | [[3g3a]] is an 8 chain structure with sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3A OCA]. | ||
| + | |||
| + | [[3g39]] is a single chain structure with sequence from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G39 OCA]. | ||
| + | |||
| + | [[3m18]] is a 2 chain structure with sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M18 OCA]. | ||
| + | |||
| + | [[3m19]] is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M19 OCA]. | ||
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| + | ==3D structures of variable lymphocyte receptor== | ||
| + | |||
| + | [[Variable lymphocyte receptor]] | ||
==References and Notes== | ==References and Notes== | ||
| - | <ref group="xtra">PMID:18818359</ref><references group="xtra"/> | + | <ref group="xtra">PMID:18818359</ref><ref group="xtra">PMID: 19543291</ref><ref group="xtra">PMID: 20616002</ref><references group="xtra"/> |
==See Also== | ==See Also== | ||
| - | [[Variable | + | * [[Variable Lymphocyte Receptors]] |
| - | [[Antibody]] | + | *[[leucine-rich repeat|Leucine-rich Repeat Proteins]] |
| + | * [[Antibody]] | ||
| + | * [[Forkhead box family]] | ||
==Additional Literature== | ==Additional Literature== | ||
| - | <ref group="xtra">PMID: 15241406</ref><ref group="xtra">PMID: 17192264</ref><ref group="xtra">PMID: 20482318</ref><ref group="xtra">PMID: 20660361</ref><ref group="xtra">PMID: 19840917</ref><references group="xtra"/> | + | <ref group="xtra">PMID: 21293377</ref><ref group="xtra">PMID: 15241406</ref><ref group="xtra">PMID: 17192264</ref><ref group="xtra">PMID: 20482318</ref><ref group="xtra">PMID: 20660361</ref><ref group="xtra">PMID: 19840917</ref><references group="xtra"/> |
| + | |||
==External Resources== | ==External Resources== | ||
| + | * [http://en.wikipedia.org/wiki/Adaptive_immune_system#Alternative_adaptive_immune_system Variable lymphocyte receptors covered in Wikipedia as an alternative adaptive immune system as part of the topic of Adaptive immune system] | ||
[[Category: Petromyzon marinus]] | [[Category: Petromyzon marinus]] | ||
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[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Sea lamprey]] | [[Category: Sea lamprey]] | ||
| + | [[Category: Lamprey]] | ||
| + | [[Category: Agnathans]] | ||
| + | [[Category: Agnatha]] | ||
[[Category: Variable lymphocyte receptor]] | [[Category: Variable lymphocyte receptor]] | ||
[[Category: Vlr]] | [[Category: Vlr]] | ||
| + | [[Category:Topic Page]] | ||
Current revision
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| Lamprey Variable Lymphocyte Receptor in complex with a trisaccharide antigen (3e6j), resolution 1.67Å () | |||||||
|---|---|---|---|---|---|---|---|
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Contents |
Crystal Structure of Variable Lymphocyte Receptor (VLR) RBC36 in Complex with H-trisaccharide
About these Structures
Lamprey VLRs are members of the Leucine-rich repeat (LRR) family of diverse proteins. Variable lymphocyte receptors are involved in the adaptative immune response.
3e6j is a single chain structure of sequence from Petromyzon marinus. Full crystallographic information is available from OCA.
3g3b is an 8 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.
3g3a is an 8 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.
3g39 is a single chain structure with sequence from Petromyzon marinus. Full crystallographic information is available from OCA.
3m18 is a 2 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.
3m19 is a 2 chains structure with sequences from Petromyzon marinus. Full crystallographic information is available from OCA.
3D structures of variable lymphocyte receptor
References and Notes
- Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
- Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
- Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA. A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proc Natl Acad Sci U S A. 2010 Jul 8. PMID:20616002
See Also
Additional Literature
- Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
- Pancer Z, Amemiya CT, Ehrhardt GR, Ceitlin J, Gartland GL, Cooper MD. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature. 2004 Jul 8;430(6996):174-80. PMID:15241406 doi:10.1038/nature02740
- Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200
- Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
- Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
- Liang J, Liu X, Wu FF, Li QW. [Progress of adaptive immunity system of agnathan vertebrates] Yi Chuan. 2009 Oct;31(10):969-76. PMID:19840917
