3mwp

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'''Unreleased structure'''
 
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The entry 3mwp is ON HOLD until Paper Publication
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==Nucleoprotein structure of lassa fever virus==
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<StructureSection load='3mwp' size='340' side='right'caption='[[3mwp]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mwp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.795&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwp OCA], [https://pdbe.org/3mwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwp RCSB], [https://www.ebi.ac.uk/pdbsum/3mwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
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Authors: Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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Description:
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__TOC__
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:29:41 2010''
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[[Category: Large Structures]]
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[[Category: Lassa virus Josiah]]
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[[Category: Dong C]]
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[[Category: Dong H]]
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[[Category: Lan S]]
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[[Category: Liang Y]]
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[[Category: Ly H]]
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[[Category: Qi X]]
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[[Category: Schelde LM]]
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[[Category: Wallat G]]
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[[Category: Wang W]]

Current revision

Nucleoprotein structure of lassa fever virus

PDB ID 3mwp

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OCA

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