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3pi5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3pi5 is ON HOLD until Paper Publication Authors: Rondeau, J.M. Description: Crystal Structure of Human Beta Secretase in Complex with BFG356 ''Pag...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Beta Secretase in Complex with BFG356== | |
| + | <StructureSection load='3pi5' size='340' side='right'caption='[[3pi5]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3pi5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PI5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3P5:(3S,4S,5R)-3-(3-BROMO-4-HYDROXYBENZYL)-5-[(3-CYCLOPROPYLBENZYL)AMINO]TETRAHYDRO-2H-THIOPYRAN-4-OL+1,1-DIOXIDE'>3P5</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pi5 OCA], [https://pdbe.org/3pi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pi5 RCSB], [https://www.ebi.ac.uk/pdbsum/3pi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pi5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rondeau JM]] | ||
Current revision
Crystal Structure of Human Beta Secretase in Complex with BFG356
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