2o6s

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(New page: 200px<br /><applet load="2o6s" size="350" color="white" frame="true" align="right" spinBox="true" caption="2o6s, resolution 1.50&Aring;" /> '''Structural diversity...)
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[[Image:2o6s.jpg|left|200px]]<br /><applet load="2o6s" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2o6s, resolution 1.50&Aring;" />
 
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'''Structural diversity of the hagfish Variable Lymphocyte Receptors B59'''<br />
 
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==Overview==
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==Structural diversity of the hagfish Variable Lymphocyte Receptors B59==
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Variable lymphocyte receptors (VLRs) are recently discovered leucine-rich, repeat (LRR) family proteins that mediate adaptive immune responses in, jawless fish. Phylogenetically it is the oldest adaptive immune receptor, and the first one with a non-immunoglobulin fold. We present the crystal, structures of one VLR-A and two VLR-B clones from the inshore hagfish. The, hagfish VLRs have the characteristic horseshoe-shaped structure of LRR, family proteins. The backbone structures of their LRR modules are highly, homologous, and the sequence variation is concentrated on the concave, surface of the protein. The conservation of key residues suggests that our, structures are likely to represent the LRR structures of the entire, repertoire of jawless fish VLRs. The analysis of sequence variability, prediction of protein interaction surfaces, amino acid composition, analysis, and structural comparison with other LRR proteins suggest that, the hypervariable concave surface is the most probable antigen binding, site of the VLR.
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<StructureSection load='2o6s' size='340' side='right'caption='[[2o6s]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2o6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O6S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6s OCA], [https://pdbe.org/2o6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o6s RCSB], [https://www.ebi.ac.uk/pdbsum/2o6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o6s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4G1L3_EPTBU Q4G1L3_EPTBU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/2o6s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o6s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Variable lymphocyte receptors (VLRs) are recently discovered leucine-rich repeat (LRR) family proteins that mediate adaptive immune responses in jawless fish. Phylogenetically it is the oldest adaptive immune receptor and the first one with a non-immunoglobulin fold. We present the crystal structures of one VLR-A and two VLR-B clones from the inshore hagfish. The hagfish VLRs have the characteristic horseshoe-shaped structure of LRR family proteins. The backbone structures of their LRR modules are highly homologous, and the sequence variation is concentrated on the concave surface of the protein. The conservation of key residues suggests that our structures are likely to represent the LRR structures of the entire repertoire of jawless fish VLRs. The analysis of sequence variability, prediction of protein interaction surfaces, amino acid composition analysis, and structural comparison with other LRR proteins suggest that the hypervariable concave surface is the most probable antigen binding site of the VLR.
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==About this Structure==
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Structural diversity of the hagfish variable lymphocyte receptors.,Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264<ref>PMID:17192264</ref>
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2O6S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6S OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural diversity of the hagfish variable lymphocyte receptors., Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO, J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17192264 17192264]
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</div>
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[[Category: Eptatretus burgeri]]
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<div class="pdbe-citations 2o6s" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Kim, H.M.]]
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[[Category: Lee, J.O.]]
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[[Category: Oh, S.C.]]
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[[Category: immune system]]
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[[Category: leucine-rich repeat protein]]
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[[Category: lrr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:39:51 2008''
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==See Also==
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Eptatretus burgeri]]
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[[Category: Large Structures]]
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[[Category: Kim HM]]
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[[Category: Lee JO]]
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[[Category: Oh SC]]

Current revision

Structural diversity of the hagfish Variable Lymphocyte Receptors B59

PDB ID 2o6s

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