3mnv

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{{Seed}}
 
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[[Image:3mnv.jpg|left|200px]]
 
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==Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment==
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The line below this paragraph, containing "STRUCTURE_3mnv", creates the "Structure Box" on the page.
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<StructureSection load='3mnv' size='340' side='right'caption='[[3mnv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mnv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3mnv| PDB=3mnv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnv OCA], [https://pdbe.org/3mnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnv RCSB], [https://www.ebi.ac.uk/pdbsum/3mnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8TCD0_HUMAN Q8TCD0_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.
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===Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment===
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Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.,Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF Nat Struct Mol Biol. 2010 Dec;17(12):1492-4. Epub 2010 Nov 14. PMID:21076400<ref>PMID:21076400</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3mnv" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3MNV is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus,homo_sapiens Mus musculus,homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNV OCA].
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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[[Category: Mus musculus,homo sapiens]]
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== References ==
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[[Category: Alam, S M.]]
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<references/>
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[[Category: Dennison, S M.]]
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__TOC__
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[[Category: Haynes, B F.]]
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</StructureSection>
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[[Category: Kelsoe, G.]]
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[[Category: Homo sapiens]]
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[[Category: Liao, H X.]]
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[[Category: Large Structures]]
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[[Category: Nicely, N I.]]
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[[Category: Mus musculus]]
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[[Category: 13h11]]
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[[Category: Alam SM]]
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[[Category: 2f5]]
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[[Category: Dennison SM]]
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[[Category: 4e10]]
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[[Category: Haynes BF]]
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[[Category: Fab antibody]]
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[[Category: Kelsoe G]]
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[[Category: Gp41]]
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[[Category: Liao H-X]]
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[[Category: Hiv]]
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[[Category: Nicely NI]]
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[[Category: Hiv-1]]
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[[Category: Immune system]]
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[[Category: Mper]]
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[[Category: Z13]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:49:55 2010''
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Current revision

Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment

PDB ID 3mnv

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