3og5

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[[Image:3og5.jpg|left|200px]]
 
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==Crystal Structure of BamA POTRA45 tandem==
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The line below this paragraph, containing "STRUCTURE_3og5", creates the "Structure Box" on the page.
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<StructureSection load='3og5' size='340' side='right'caption='[[3og5]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3og5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OG5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3og5| PDB=3og5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3og5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3og5 OCA], [https://pdbe.org/3og5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3og5 RCSB], [https://www.ebi.ac.uk/pdbsum/3og5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3og5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAMA_ECOLI BAMA_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.<ref>PMID:15951436</ref> <ref>PMID:16102012</ref> <ref>PMID:16824102</ref> <ref>PMID:20378773</ref> <ref>PMID:21823654</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Folding and insertion of beta-barrel outer membrane proteins (OMPs) is essential for Gram-negative bacteria. This process is mediated by the multiprotein complex BAM, composed of the essential beta-barrel OMP BamA and four lipoproteins (BamBCDE). The periplasmic domain of BamA is key for its function and contains five "polypeptide transport-associated" (POTRA) repeats. Here, we report the crystal structure of the POTRA4-5 tandem, containing the essential for BAM complex formation and cell viability POTRA5. The domain orientation observed in the crystal is validated by solution NMR and SAXS. Using previously determined structures of BamA POTRA1-4, we present a spliced model of the entire BamA periplasmic domain validated by SAXS. Solution scattering shows that conformational flexibility between POTRA2 and 3 gives rise to compact and extended conformations. The length of BamA in its extended conformation suggests that the protein may bridge the inner and outer membranes across the periplasmic space.
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===Crystal Structure of BamA POTRA45 tandem===
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Structure and flexibility of the complete periplasmic domain of BamA: the protein insertion machine of the outer membrane.,Gatzeva-Topalova PZ, Warner LR, Pardi A, Sousa MC Structure. 2010 Nov 10;18(11):1492-501. PMID:21070948<ref>PMID:21070948</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3og5" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3OG5 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG5 OCA].
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*[[Bam complex 3D structures|Bam complex 3D structures]]
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[[Category: Escherichia coli]]
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== References ==
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[[Category: Gatzeva-Topalova, P Z.]]
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<references/>
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[[Category: Pardi, A.]]
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__TOC__
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[[Category: Sousa, M C.]]
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</StructureSection>
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[[Category: Warner, L R.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Insertion of outer membrane protein]]
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[[Category: Large Structures]]
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[[Category: Potra fold]]
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[[Category: Gatzeva-Topalova PZ]]
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[[Category: Protein binding]]
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[[Category: Pardi A]]
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[[Category: Sousa MC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:52:49 2010''
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[[Category: Warner LR]]

Current revision

Crystal Structure of BamA POTRA45 tandem

PDB ID 3og5

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