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2jax
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(New page: 200px<br /><applet load="2jax" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jax, resolution 3.22Å" /> '''UNIVERSAL STRESS PRO...) |
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| - | [[Image:2jax.jpg|left|200px]]<br /><applet load="2jax" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jax, resolution 3.22Å" /> | ||
| - | '''UNIVERSAL STRESS PROTEIN RV2623 FROM MYCOBATERIUM TUBERCULOSIS'''<br /> | ||
| - | == | + | ==Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis== |
| - | + | <StructureSection load='2jax' size='340' side='right'caption='[[2jax]], [[Resolution|resolution]] 3.22Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[2jax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAX FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jax OCA], [https://pdbe.org/2jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jax RCSB], [https://www.ebi.ac.uk/pdbsum/2jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jax ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function. |
| - | [[Category: | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jax_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jax ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Bartunik HD]] | ||
| + | [[Category: Bourenkov G]] | ||
| + | [[Category: Oberschall A]] | ||
| + | [[Category: Strizhov N]] | ||
Current revision
Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis
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