Sandbox c5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:41, 23 November 2010) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
HOLA
+
<Structure load='1acj' size='500' frame='true' align='right' caption='estructura favorita' />1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
 +
 
 +
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
 +
 
 +
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
 +
 
 +
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .
 +
 
 +
<scene name='Sandbox_c5/Tacrine1/1'>(W84 and F330)</scene>
 +
<ref>PIMID 8415649</ref>
 +
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
 +
<references/>

Current revision

estructura favorita

Drag the structure with the mouse to rotate
1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .

[1] Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

  1. ↑ PIMID 8415649
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_c5"
Personal tools