Sandbox c12
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 7: | Line 7: | ||
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
| - | <scene name=' | + | <scene name='User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1'>attached to the Fe</scene> |
| + | <scene name='Sandbox_c12/Label/1'>Tacrines ring</scene> is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c12/Residuos_84_y_330/1'>W84 and F330</scene>)<ref>pmid 8415649</ref> | ||
| + | |||
<references/> | <references/> | ||
| - | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | ||
Current revision
|
1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ()[1]
