Sandbox c12

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ()^[1]

↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

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 It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
-<scene name='Sandbox_c12/Label/1'>Tacrines ring</scene> is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c12/Residuos_84_y_330/1'>W84 and F330</scene>)<ref>pmid 123</ref>
+<scene name='User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1'>attached to the Fe</scene>
+<scene name='Sandbox_c12/Label/1'>Tacrines ring</scene> is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c12/Residuos_84_y_330/1'>W84 and F330</scene>)<ref>pmid 8415649</ref>
-Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.
-<references/>pmid 123
+<references/>