2qt7

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(New page: 200px<br /><applet load="2qt7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qt7, resolution 1.30&Aring;" /> '''Crystallographic str...)
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[[Image:2qt7.jpg|left|200px]]<br /><applet load="2qt7" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qt7, resolution 1.30&Aring;" />
 
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'''Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms'''<br />
 
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==Overview==
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==Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms==
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IA-2 is a protein-tyrosine phosphatase receptor located in secretory, granules of neuroendocrine cells. Initially, it attracted attention due to, its involvement in the autoimmune response associated to diabetes. Later, it was found that upon exocytosis, the cytoplasmic domain of IA-2 is, cleaved and relocated to the nucleus, where it enhances the transcription, of the insulin gene. A concerted functioning of the whole receptor is to, be expected. However, very little is known about the structure and, function of the transmembrane and extracellular domains of IA-2. To, address this issue, we solved the X-ray structure of the mature ectodomain, of IA-2 (meIA-2) to 1.30 A resolution. The fold of meIA-2 is related to, the SEA domains of mucins, suggesting its participation in adhesive, contacts to the extracellular matrix, and providing clues on how this kind, of molecules may associate and form homo- and heterodimers. Moreover, we, discovered that meIA-2 is self proteolyzed in vitro by reactive oxygen, species, suggesting the possibility of a new shedding mechanism that might, be significant in normal function or pathological processes. Knowledge of, meIA-2 structure should facilitate the search of its possible ligands and, molecular interactions.
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<StructureSection load='2qt7' size='340' side='right'caption='[[2qt7]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qt7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QT7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt7 OCA], [https://pdbe.org/2qt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qt7 RCSB], [https://www.ebi.ac.uk/pdbsum/2qt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qt7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qt7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qt7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2QT7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT7 OCA].
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2., Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR, J Biol Chem. 2007 Nov 29;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18048354 18048354]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Ermacora MR]]
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[[Category: Ermacora, M.R.]]
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[[Category: Goldbaum FA]]
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[[Category: Goldbaum, F.A.]]
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[[Category: Jakoncic J]]
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[[Category: Jakoncic, J.]]
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[[Category: Klinke S]]
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[[Category: Klinke, S.]]
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[[Category: Poskus E]]
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[[Category: Poskus, E.]]
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[[Category: Primo ME]]
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[[Category: Primo, M.E.]]
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[[Category: Sica MP]]
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[[Category: Sica, M.P.]]
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[[Category: CA]]
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[[Category: autoimmunity]]
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[[Category: diabetes]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: ia-2]]
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[[Category: ica-512]]
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[[Category: protein-tyrosine phosphatase]]
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[[Category: proteolysis]]
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[[Category: receptor]]
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[[Category: transmembrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:44:56 2008''
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Current revision

Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms

PDB ID 2qt7

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