2xyk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2xyk is ON HOLD Authors: Pesce, A., Nardini, M., LaBarre, M., Richard, C., Wittenberg, J.B., Wittenberg, B.A., Guertin, M., Bolognesi, M. Descripti...) |
|||
| (11 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens== | |
| + | <StructureSection load='2xyk' size='340' side='right'caption='[[2xyk]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2xyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XYK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyk OCA], [https://pdbe.org/2xyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xyk RCSB], [https://www.ebi.ac.uk/pdbsum/2xyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q7CX73_AGRFC Q7CX73_AGRFC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Within the 2/2 hemoglobin sub-family, no group II 2/2Hbs from proteobacteria have been so far studied. Here we present the first structural characterization of a group II 2/2Hb from the soil and phytopathogenic bacterium Agrobacterium tumefaciens (At-2/2HbO). The crystal structure of ferric At-2/2HbO (reported at 2.1A resolution) shows the location of specific/unique heme distal site residues (e.g., His(42)CD1, a residue distinctive of proteobacteria group II 2/2Hbs) that surround a heme-liganded water molecule. A highly intertwined hydrogen-bonded network, involving residues Tyr(26)B10, His(42)CD1, Ser(49)E7, Trp(93)G8, and three distal site water molecules, stabilizes the heme-bound ligand. Such a structural organization suggests a path for diatomic ligand diffusion to/from the heme. Neither a similar distal site structuring effect nor the presence of distal site water molecules has been so far observed in group I and group III 2/2Hbs, thus adding new distinctive information to the complex picture of currently available 2/2Hb structural and functional data. | ||
| - | + | Structural characterization of a group II 2/2 hemoglobin from the plant pathogen Agrobacterium tumefaciens.,Pesce A, Nardini M, Labarre M, Richard C, Wittenberg JB, Wittenberg BA, Guertin M, Bolognesi M Biochim Biophys Acta. 2010 Nov 9. PMID:21070893<ref>PMID:21070893</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2xyk" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| + | *[[Hemoglobin 3D structures|Hemoglobin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Agrobacterium tumefaciens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bolognesi M]] | ||
| + | [[Category: Guertin M]] | ||
| + | [[Category: LaBarre M]] | ||
| + | [[Category: Nardini M]] | ||
| + | [[Category: Pesce A]] | ||
| + | [[Category: Richard C]] | ||
| + | [[Category: Wittenberg BA]] | ||
| + | [[Category: Wittenberg JB]] | ||
Current revision
Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens
| |||||||||||
