2kwa

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{{Seed}}
 
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[[Image:2kwa.jpg|left|200px]]
 
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==1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis==
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The line below this paragraph, containing "STRUCTURE_2kwa", creates the "Structure Box" on the page.
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<StructureSection load='2kwa' size='340' side='right'caption='[[2kwa]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kwa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KWA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwa OCA], [https://pdbe.org/2kwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kwa RCSB], [https://www.ebi.ac.uk/pdbsum/2kwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kwa ProSAT]</span></td></tr>
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{{STRUCTURE_2kwa| PDB=2kwa | SCENE= }}
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</table>
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== Function ==
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===1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis===
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[https://www.uniprot.org/uniprot/PXPB_BACSU PXPB_BACSU] Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (PubMed:28830929). In addition, is a potent inhibitor of the autophosphorylation reaction of kinase A (kinA) and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. Is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is non-competitive with respect to ATP (PubMed:9334321).<ref>PMID:28830929</ref> <ref>PMID:9334321</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21050859 is the PubMed ID number.
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21050859}}
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[[Category: Hynson RMG]]
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[[Category: Jacques DA]]
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==About this Structure==
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[[Category: Kwan A]]
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2KWA is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KWA OCA].
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[[Category: Mackay JP]]
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[[Category: Trewhella J]]
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==Reference==
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<ref group="xtra">PMID:21050859</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
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[[Category: Hynson, R M.G.]]
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[[Category: Jacques, D A.]]
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[[Category: Kwan, A.]]
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[[Category: Mackay, J P.]]
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[[Category: Trewhella, J.]]
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[[Category: Bacillus subtili]]
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[[Category: Bacterial signal transduction]]
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[[Category: Histidine kinase inhibition]]
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[[Category: Kipi]]
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[[Category: Transferase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:09:50 2010''
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Current revision

1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis

PDB ID 2kwa

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