1a8f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:22, 13 March 2024) (edit) (undo)
 
(23 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a8f.gif|left|200px]]<br />
 
-
<applet load="1a8f" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1a8f, resolution 1.80&Aring;" />
 
-
'''HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE'''<br />
 
-
==Overview==
+
==HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE==
-
The N-lobe of human serum transferrin (hTF/2N) has been expressed in baby, hamster kidney cells and crystallized in both orthorhombic (P212121) and, tetragonal (P41212) space groups. Both crystal forms diffract to high, resolution (1.6 and 1.8 A, respectively) and have been solved by molecular, replacement. Subsequent refinement resulted in final models for the, structure of hTF/2N that had crystallographic R-factors of 18.1 and 19.7%, for the two crystal forms, respectively; these models represent the, highest-resolution transferrin structures determined to date. The hTF/2N, polypeptide has a folding pattern similar to those of other transferrins, including the presence of a deep cleft that contains the metal-binding, site. In contrast to other transferrins, both crystal forms of hTF/2N, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9609685 (full description)]]
+
<StructureSection load='1a8f' size='340' side='right'caption='[[1a8f]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1a8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8F FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8f OCA], [https://pdbe.org/1a8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8f RCSB], [https://www.ebi.ac.uk/pdbsum/1a8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8f ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8f_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8f ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1A8F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CO3 and FE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: FE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A8F OCA]].
+
*[[Transferrin 3D structures|Transferrin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release., MacGillivray RT, Moore SA, Chen J, Anderson BF, Baker H, Luo Y, Bewley M, Smith CA, Murphy ME, Wang Y, Mason AB, Woodworth RC, Brayer GD, Baker EN, Biochemistry. 1998 Jun 2;37(22):7919-28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9609685 9609685]
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Anderson, B.F.]]
+
[[Category: Anderson BF]]
-
[[Category: Baker, E.N.]]
+
[[Category: Baker EN]]
-
[[Category: Baker, H.]]
+
[[Category: Baker H]]
-
[[Category: Bewley, M.]]
+
[[Category: Bewley M]]
-
[[Category: Brayer, G.D.]]
+
[[Category: Brayer GD]]
-
[[Category: Chen, J.]]
+
[[Category: Chen J]]
-
[[Category: Luo, Y.]]
+
[[Category: Luo Y]]
-
[[Category: Macgillivray, R.T.A.]]
+
[[Category: Macgillivray RTA]]
-
[[Category: Mason, A.B.]]
+
[[Category: Mason AB]]
-
[[Category: Moore, S.A.]]
+
[[Category: Moore SA]]
-
[[Category: Murphy, M.E.P.]]
+
[[Category: Murphy MEP]]
-
[[Category: Smith, C.A.]]
+
[[Category: Smith CA]]
-
[[Category: Wang, Y.]]
+
[[Category: Wang Y]]
-
[[Category: Woodworth, R.C.]]
+
[[Category: Woodworth RC]]
-
[[Category: CO3]]
+
-
[[Category: FE]]
+
-
[[Category: carbonate]]
+
-
[[Category: glycoprotein]]
+
-
[[Category: iron transport]]
+
-
[[Category: iron-release]]
+
-
[[Category: nlobe]]
+
-
[[Category: transferrin]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:12:27 2007''
+

Current revision

HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE

PDB ID 1a8f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a8f"
Personal tools