2xxz

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{{Seed}}
 
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[[Image:2xxz.png|left|200px]]
 
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==Crystal structure of the human JMJD3 jumonji domain==
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The line below this paragraph, containing "STRUCTURE_2xxz", creates the "Structure Box" on the page.
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<StructureSection load='2xxz' size='340' side='right'caption='[[2xxz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XQ:8-HYDROXYQUINOLINE-5-CARBOXYLIC+ACID'>8XQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_2xxz| PDB=2xxz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxz OCA], [https://pdbe.org/2xxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxz RCSB], [https://www.ebi.ac.uk/pdbsum/2xxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>
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===CRYSTAL STRUCTURE OF THE HUMAN JMJD3 JUMONJI DOMAIN===
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2XXZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXZ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Bountra C]]
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[[Category: Che, K H.]]
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[[Category: Burgess-Brown N]]
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[[Category: Daniel, M.]]
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[[Category: Che KH]]
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[[Category: Edwards, A.]]
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[[Category: Daniel M]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Edwards A]]
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[[Category: Krojer, T.]]
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[[Category: Filippakopoulos P]]
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[[Category: Muniz, J R.C.]]
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[[Category: Krojer T]]
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[[Category: Ng, S S.]]
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[[Category: Muniz JRC]]
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[[Category: Oppermann, U.]]
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[[Category: Ng SS]]
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[[Category: Savitsky, P.]]
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[[Category: Oppermann U]]
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[[Category: Tumber, A.]]
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[[Category: Savitsky P]]
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[[Category: Ugochukwu, E.]]
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[[Category: Tumber A]]
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[[Category: Weigelt, J.]]
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[[Category: Ugochukwu E]]
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[[Category: Yue, W W.]]
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[[Category: Weigelt J]]
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[[Category: Chromatin modification]]
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[[Category: Yue WW]]
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[[Category: Histone demethylation]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:00:19 2010''
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Current revision

Crystal structure of the human JMJD3 jumonji domain

PDB ID 2xxz

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