3aqy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3aqy is ON HOLD Authors: Kanagawa, M., Satoh, T., Ohno, N., Adachi, Y., Yamaguchi, Y. Description: Crystal structure of insect lectin from Plodia i...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain== | |
| + | <StructureSection load='3aqy' size='340' side='right'caption='[[3aqy]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3aqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqy OCA], [https://pdbe.org/3aqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aqy RCSB], [https://www.ebi.ac.uk/pdbsum/3aqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BGBP_PLOIN BGBP_PLOIN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Innate ability to detect pathogens is achieved by pattern recognition receptors (PRRs) which recognise non-self components such as beta1,3-glucan. beta1,3-Glucans form a triple-helical structure stabilised by inter-chain hydrogen bonds. beta1,3-Glucan recognition protein (betaGRP)/gram-negative bacteria-binding protein 3 (GNBP3), one of PPRs, binds to long, structured beta1,3-glucan to initiate innate immune response. However, binding details and how specificity is achieved in such receptors remain important outstanding issues. We solved the crystal structures of the N-terminal beta1,3-glucan recognition domain of betaGRP/GNBP3 (betaGRP-N) in complex with the beta1,3-linked glucose hexamer, laminarihexaose. In the crystals, three structured laminarihexaoses simultaneously interact through six glucose residues (two from each chain) with one betaGRP-N. The spatial arrangement of the laminarihexaoses bound to betaGRP-N is almost identical to that of a beta1,3-glucan triplex. Therefore, our crystallographic structures together with site-directed mutagenesis data provide a structural basis for the unique recognition by such receptors of the triple-helix structure of beta1,3-glucan. | ||
| - | + | Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor.,Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y J Biol Chem. 2011 Jun 22. PMID:21697086<ref>PMID:21697086</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3aqy" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plodia interpunctella]] | ||
| + | [[Category: Adachi Y]] | ||
| + | [[Category: Ikeda A]] | ||
| + | [[Category: Kanagawa M]] | ||
| + | [[Category: Ohno N]] | ||
| + | [[Category: Satoh T]] | ||
| + | [[Category: Yamaguchi Y]] | ||
Current revision
Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain
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