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3akj

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{{Seed}}
 
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[[Image:3akj.jpg|left|200px]]
 
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==Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA==
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The line below this paragraph, containing "STRUCTURE_3akj", creates the "Structure Box" on the page.
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<StructureSection load='3akj' size='340' side='right'caption='[[3akj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3akj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3akj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3akj OCA], [https://pdbe.org/3akj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3akj RCSB], [https://www.ebi.ac.uk/pdbsum/3akj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3akj ProSAT]</span></td></tr>
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{{STRUCTURE_3akj| PDB=3akj | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA===
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[https://www.uniprot.org/uniprot/CTKA_HELPJ CTKA_HELPJ] Virulence factor acting as a pro-inflammatory protein that induces the secretion of the pro-inflammatory cytokines TNF-alpha (tumor necrosis factor-alpha) and IL-8 (interleukin-8) from human macrophages, as well as enhanced translocation of the transcription factor NF-kappa-B complex in macrophages. Is a kinase capable of autophosphorylating itself at a threonine residue near the N-terminus. Also leads to enhanced phosphorylation of the NF-kappa-B p65 subunit (RELA) at 'Ser-276' in human epithelial cancer cells; its kinase activity is required for this enhanced phosphorylation that up-regulates NF-kappa-B activity, but it does not directly phosphorylate this protein. Thus, the kinase activity of CtkA may play an important role in the induction of host inflammatory responses during H.pylori infection.<ref>PMID:17993522</ref> <ref>PMID:21098302</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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3AKJ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKJ OCA].
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</StructureSection>
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[[Category: Helicobacter pylori]]
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[[Category: Helicobacter pylori J99]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Kim, D J.]]
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[[Category: Kim DJ]]
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[[Category: Suh, S W.]]
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[[Category: Suh SW]]
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[[Category: Protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:28:56 2010''
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Current revision

Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA

PDB ID 3akj

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