3an1

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{{Seed}}
 
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[[Image:3an1.jpg|left|200px]]
 
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==Crystal structure of rat D428A mutant, urate bound form==
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The line below this paragraph, containing "STRUCTURE_3an1", creates the "Structure Box" on the page.
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<StructureSection load='3an1' size='340' side='right'caption='[[3an1]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3an1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AN1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
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{{STRUCTURE_3an1| PDB=3an1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3an1 OCA], [https://pdbe.org/3an1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3an1 RCSB], [https://www.ebi.ac.uk/pdbsum/3an1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3an1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XDH_RAT XDH_RAT] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.<ref>PMID:17301076</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two contradictory models have been proposed for the binding mode of the substrate xanthine to and its activation mechanism by xanthine oxidoreductase. In an effort to distinguish between the two models, we determined the crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase at 1.7 A and of the reduced bovine milk enzyme at 2.1 A, the latter representing a reaction intermediate. The results clearly indicate the catalytically relevant binding mode of the substrate xanthine.
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===Crystal structure of rat D428A mutant, urate bound form===
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Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate.,Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T J Am Chem Soc. 2010 Nov 15. PMID:21077683<ref>PMID:21077683</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3an1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Xanthine dehydrogenase 3D structures|Xanthine dehydrogenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21077683 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21077683}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3AN1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AN1 OCA].
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==Reference==
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<ref group="xtra">PMID:21077683</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Eger, B T.]]
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[[Category: Eger BT]]
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[[Category: Kawaguchi, Y.]]
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[[Category: Kawaguchi Y]]
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[[Category: Nishino, T.]]
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[[Category: Nishino T]]
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[[Category: Okamoto, K.]]
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[[Category: Okamoto K]]
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[[Category: Pai, E F.]]
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[[Category: Pai EF]]
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[[Category: Oxidoreductase]]
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[[Category: Product bound form]]
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[[Category: Urate binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:29:20 2010''
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Current revision

Crystal structure of rat D428A mutant, urate bound form

PDB ID 3an1

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