3kd0

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{{Seed}}
 
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[[Image:3kd0.jpg|left|200px]]
 
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==Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site==
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The line below this paragraph, containing "STRUCTURE_3kd0", creates the "Structure Box" on the page.
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<StructureSection load='3kd0' size='340' side='right'caption='[[3kd0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KD0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_3kd0| PDB=3kd0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kd0 OCA], [https://pdbe.org/3kd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kd0 RCSB], [https://www.ebi.ac.uk/pdbsum/3kd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kd0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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===Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site===
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==See Also==
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3KD0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD0 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Emsley, J.]]
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[[Category: Large Structures]]
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[[Category: Hall, G.]]
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[[Category: Emsley J]]
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[[Category: Disulfide bond]]
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[[Category: Hall G]]
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[[Category: Electron transport]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin fold]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:30:12 2010''
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Current revision

Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site

PDB ID 3kd0

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