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3nx0

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{{Seed}}
 
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[[Image:3nx0.jpg|left|200px]]
 
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==Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C==
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The line below this paragraph, containing "STRUCTURE_3nx0", creates the "Structure Box" on the page.
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<StructureSection load='3nx0' size='340' side='right'caption='[[3nx0]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NX0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3nx0| PDB=3nx0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nx0 OCA], [https://pdbe.org/3nx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nx0 RCSB], [https://www.ebi.ac.uk/pdbsum/3nx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nx0 ProSAT]</span></td></tr>
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</table>
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===Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C===
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== Disease ==
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[https://www.uniprot.org/uniprot/CYTC_HUMAN CYTC_HUMAN] Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:[https://omim.org/entry/105150 105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.<ref>PMID:2541223</ref> <ref>PMID:1352269</ref> Genetic variations in CST3 are associated with age-related macular degeneration type 11 (ARMD11) [MIM:[https://omim.org/entry/611953 611953]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.<ref>PMID:11815350</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CYTC_HUMAN CYTC_HUMAN] As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_21074623}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21074623 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21074623}}
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</StructureSection>
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==About this Structure==
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3NX0 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX0 OCA].
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==Reference==
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<ref group="xtra">PMID:21074623</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jankowska, E.]]
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[[Category: Large Structures]]
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[[Category: Jaskolski, M.]]
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[[Category: Jankowska E]]
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[[Category: Kolodziejczyk, R.]]
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[[Category: Jaskolski M]]
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[[Category: Orlikowska, M.]]
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[[Category: Kolodziejczyk R]]
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[[Category: Szymanska, A.]]
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[[Category: Orlikowska M]]
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[[Category: 3d domain swapping]]
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[[Category: Szymanska A]]
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[[Category: Amyloid]]
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[[Category: Cysteine protease inhibitor]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Protein aggregation]]
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[[Category: Protein engineering]]
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[[Category: Protein oligomerization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:32:47 2010''
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Current revision

Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C

PDB ID 3nx0

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