3pg6

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{{Seed}}
 
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[[Image:3pg6.jpg|left|200px]]
 
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==The carboxyl terminal domain of human deltex 3-like==
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The line below this paragraph, containing "STRUCTURE_3pg6", creates the "Structure Box" on the page.
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<StructureSection load='3pg6' size='340' side='right'caption='[[3pg6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pg6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PG6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3pg6| PDB=3pg6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg6 OCA], [https://pdbe.org/3pg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3pg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DTX3L_HUMAN DTX3L_HUMAN] Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.<ref>PMID:12670957</ref> <ref>PMID:19818714</ref> <ref>PMID:23230272</ref>
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===The carboxyl terminal domain of human deltex 3-like===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3PG6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG6 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Kania, J.]]
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[[Category: Edwards AM]]
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[[Category: Obiero, J.]]
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[[Category: Kania J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Obiero J]]
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[[Category: Schuler, H.]]
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[[Category: Schuler H]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Chromatin regulator]]
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[[Category: Dna-damage]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:35:47 2010''
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Current revision

The carboxyl terminal domain of human deltex 3-like

PDB ID 3pg6

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