HIV Protease Resistance

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{| class="wikitable" border="1" width="98%" style="text-align:center"
{| class="wikitable" border="1" width="98%" style="text-align:center"
|-
|-
-
! colspan="37" align="center"| Resistance Mutations <ref>PMID:17646201</ref><ref>PMID: 20068260</ref><ref>PMID: 14724329</ref>
+
! colspan="40" align="center"| Resistance Mutations
|-
|-
-
! Inhibitor/Mutation Site
+
!
 +
!Inhibitor/ Mutation Site
!L10
!L10
 +
!V11
!I13
!I13
!G16
!G16
Line 22: Line 24:
!F53
!F53
!I54
!I54
 +
!Q58
!D60
!D60
!I62
!I62
Line 41: Line 44:
!I93
!I93
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Ritonavir/3'>Visualize</scene>
-
!L10
+
![[Ritonavir]]
-
!I13
+
!I,R,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!M,R
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!F
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!I
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!<font color='red'>V,L</font>
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!<font color='red'>I</font>
-
!I85
+
!<font color='red'>A,F,T, S</font>
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Indinavir/4'>Visualize</scene>
-
!L10
+
![[Indinavir]]
-
!I13
+
!I,R,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!M,R
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!I
-
!I47
+
!-
-
!G48
+
!<font color='red'>I,L</font>
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!V
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!<font color='red'>S,A</font>
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!<font color='red'>I</font>
-
!I85
+
!<font color='red'>A,F,T</font>
-
!N88
+
!
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Saquinavir/2'>Visualize</scene>
-
!L10
+
![[Saquinavir]]
-
!I13
+
!I,R,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!V,L
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!<font color='red'>S</font>
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!<font color='red'>I</font>
-
!I85
+
!A
-
!N88
+
!-
-
!L89
+
!V
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Nelfinavir/1'>Visualize</scene>
-
!L10
+
![[Nelfinavir]]
-
!I13
+
!F,I
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!<font color='red'>N</font>
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!I
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!I
-
!I85
+
!A,F,T, S
-
!N88
+
!-
-
!L89
+
!V
-
!L90
+
!-
-
!I93
+
!D,S
 +
!
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Amprenavir/1'>Visualize</scene>
-
!L10
+
![[Amprenavir]]
-
!I13
+
!F,I,R, V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!V
-
!F53
+
!-
-
!I54
+
!<font color='red'>V</font>
-
!D60
+
!-
-
!I62
+
!L,V,M
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!S
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Atazanavir/1'>Visualize</scene>
-
!L10
+
![[Atazanavir]]
-
!I13
+
!I,F,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!R,M,I
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!I,F,V
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!I,L,V
-
!I47
+
!-
-
!G48
+
!I
-
!I50
+
!-
-
!F53
+
!V
-
!I54
+
!<font color='red'>L</font>
-
!D60
+
!-
-
!I62
+
!L
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V
-
!V77
+
!C,S,T, A
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!A
-
!N88
+
!-
-
!L89
+
!V
-
!L90
+
!-
-
!I93
+
!S
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Lopinavir_and_ritonavir/1'>Visualize</scene>
-
!L10
+
![[Lopinavir]] & [[Ritonavir]]
-
!I13
+
!F,I,R, V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!M,R
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!<font color='red'>I</font>
-
!E35
+
!F
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!<font color='red'>V,A</font>
-
!F53
+
!-
-
!I54
+
!V
-
!D60
+
!L
-
!I62
+
!V,L,A, M,T,S
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!P
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!S
-
!V82
+
!-
-
!N83
+
!<font color='red'>V</font>
-
!I84
+
!-
-
!I85
+
!<font color='red'>A,F,T, S</font>
-
!N88
+
!-
-
!L89
+
!V
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Atazanavir_and_ritonavir/1'>Visualize</scene>
-
!L10
+
![[Atazanavir]] & [[Ritonavir]]
-
!I13
+
!I,F,V, C
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!E
-
!D30
+
!R,M,I, T,V
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!I,F,V
-
!M36
+
!Q
-
!K43
+
!-
-
!M46
+
!I,L,V
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!-
-
!F53
+
!V
-
!I54
+
!<font color='red'>V</font>
-
!D60
+
!L,Y
-
!I62
+
!L,V,M, T,A
-
!L63
+
!-
-
!I64
+
!E
-
!H69
+
!V
-
!A71
+
!-
-
!G73
+
!L,M,V
-
!T74
+
!-
-
!L76
+
!V,I,T, L
-
!V77
+
!C,S,T, A
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!A,T,F, I
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!V
-
!I93
+
!<font color='red'>S</font>
 +
!-
 +
!M
 +
!L,M
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Darunavir_and_ritonavir/1'>Visualize</scene>
-
!L10
+
![[Darunavir]] & [[Ritonavir]]
-
!I13
+
!-
-
!G16
+
!I
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!F
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!<font color='red'>V</font>
-
!F53
+
!-
-
!I54
+
!<font color='red'>V</font>
-
!D60
+
!-
-
!I62
+
!<font color='red'>M,L</font>
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!-
-
!V82
+
!P
-
!N83
+
!<font color='red'>V</font>
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!V
 +
!-
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Fosamprenavir_and_ritonavir/1'>Visualize</scene>
-
!L10
+
![[Fosamprenavir]] & [[Ritonavir]]
-
!I13
+
!F,I,R, V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!I,L
-
!I50
+
!V
-
!F53
+
!-
-
!I54
+
!<font color='red'>V</font>
-
!D60
+
!-
-
!I62
+
!L,V,M
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!S
-
!V82
+
!-
-
!N83
+
!V
-
!I84
+
!-
-
!I85
+
!A,F,S, T
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Indinavir_and_ritonair/1'>Visualize</scene>
-
!L10
+
![[Indinavir]] & [[Ritonavir]]
-
!I13
+
!I,R,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!M,R
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!I
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!I
-
!I47
+
!-
-
!G48
+
!<font color='red'>I,L</font>
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!V
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!S,A
-
!V82
+
!-
-
!N83
+
!V
-
!I84
+
!I
-
!I85
+
!<font color='red'>A,F,T</font>
-
!N88
+
!-
-
!L89
+
!<font color='red'>V</font>
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
+
!<scene name='HIV_Protease_Resistance/Saquinavir_and_ritonavir/1'>Visualize</scene>
-
!L10
+
![[Saquinavir]] & [[Ritonavir]]
-
!I13
+
!I,R,V
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!I
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!V,L
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!V
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!V,T
-
!V77
+
!S
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!I
-
!I85
+
!A,F,T, S
-
!N88
+
!-
-
!L89
+
!V
-
!L90
+
!-
-
!I93
+
!-
 +
!-
 +
!<font color='red'>M</font>
 +
!-
 +
|-
 +
!<scene name='HIV_Protease_Resistance/Tip_and_rot/1'>Visualize</scene>
 +
![[Tipranavir]] & [[Ritonavir]]
 +
!V
 +
!-
 +
!V
 +
!-
 +
!M,R
 +
!-
 +
!-
 +
!-
 +
!F
 +
!-
 +
!G
 +
!I
 +
!T
 +
!L
 +
!<font color='red'>V</font>
 +
!-
 +
!-
 +
!-
 +
!A,M,V
 +
!<font color='red'>E<font>
 +
!-
 +
!-
 +
!-
 +
!-
 +
!K
 +
!-
 +
!-
 +
!<font color='red'>P</font>
 +
!-
 +
!-
 +
!<font color='red'>L,T</font>
 +
!D
 +
!<font color='red'>V</font>
 +
!-
 +
!-
 +
!-
 +
!M
 +
!-
|-
|-
-
! Inhibitor/Mutation Site
 
-
!L10
 
-
!I13
 
-
!G16
 
-
!K20
 
-
!L24
 
-
!D30
 
-
!V32
 
-
!L33
 
-
!E34
 
-
!E35
 
-
!M36
 
-
!K43
 
-
!M46
 
-
!I47
 
-
!G48
 
-
!I50
 
-
!F53
 
-
!I54
 
-
!D60
 
-
!I62
 
-
!L63
 
-
!I64
 
-
!H69
 
-
!A71
 
-
!G73
 
-
!T74
 
-
!L76
 
-
!V77
 
-
!V82
 
-
!N83
 
-
!I84
 
-
!I85
 
-
!N88
 
-
!L89
 
-
!L90
 
-
!I93
 
|}
|}

Current revision

Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

Proteopedia Page Contributors and Editors (what is this?)

David Canner

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