HIV Protease Resistance

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{| class="wikitable" border="1" width="98%" style="text-align:center"
{| class="wikitable" border="1" width="98%" style="text-align:center"
|-
|-
-
! colspan="38" align="center"| Resistance Mutations
+
! colspan="40" align="center"| Resistance Mutations
|-
|-
-
!Visualize
+
!
-
!Inhibitor/Mutation Site
+
!Inhibitor/ Mutation Site
!L10
!L10
 +
!V11
!I13
!I13
!G16
!G16
Line 23: Line 24:
!F53
!F53
!I54
!I54
 +
!Q58
!D60
!D60
!I62
!I62
Line 42: Line 44:
!I93
!I93
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Ritonavir/3'>Visualize</scene>
![[Ritonavir]]
![[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!<font color='red'>V,L</font>
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!-
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!<font color='red'>I</font>
-
!I84
+
!<font color='red'>A,F,T, S</font>
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Indinavir/4'>Visualize</scene>
![[Indinavir]]
![[Indinavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!<font color='red'>I,L</font>
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!<font color='red'>S,A</font>
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!<font color='red'>I</font>
-
!I84
+
!<font color='red'>A,F,T</font>
-
!I85
+
!
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir/2'>Visualize</scene>
![[Saquinavir]]
![[Saquinavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!<font color='red'>V</font>
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V,L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!<font color='red'>S</font>
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!<font color='red'>I</font>
-
!I84
+
!A
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Nelfinavir/1'>Visualize</scene>
![[Nelfinavir]]
![[Nelfinavir]]
-
!L10
+
!F,I
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!<font color='red'>N</font>
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!-
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!I
-
!I84
+
!A,F,T, S
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!D,S
-
!I93
+
!
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Amprenavir/1'>Visualize</scene>
![[Amprenavir]]
![[Amprenavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!V
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!L,V,M
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir/1'>Visualize</scene>
![[Atazanavir]]
![[Atazanavir]]
-
!L10
+
!I,F,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!R,M,I
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!I,F,V
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I,L,V
-
!M46
+
!-
-
!I47
+
!I
-
!G48
+
!-
-
!I50
+
!V
-
!F53
+
!<font color='red'>L</font>
-
!I54
+
!-
-
!D60
+
!L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V
-
!L76
+
!C,S,T, A
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!A
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!S
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Lopinavir_and_ritonavir/1'>Visualize</scene>
![[Lopinavir]] & [[Ritonavir]]
![[Lopinavir]] & [[Ritonavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!<font color='red'>I</font>
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!<font color='red'>V,A</font>
-
!I50
+
!-
-
!F53
+
!V
-
!I54
+
!L
-
!D60
+
!V,L,A, M,T,S
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!P
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!<font color='red'>V</font>
-
!N83
+
!-
-
!I84
+
!<font color='red'>A,F,T, S</font>
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir_and_ritonavir/1'>Visualize</scene>
![[Atazanavir]] & [[Ritonavir]]
![[Atazanavir]] & [[Ritonavir]]
-
!L10
+
!I,F,V, C
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!E
-
!L24
+
!R,M,I, T,V
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!I,F,V
-
!E35
+
!Q
-
!M36
+
!-
-
!K43
+
!I,L,V
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!V
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!L,Y
-
!D60
+
!L,V,M, T,A
-
!I62
+
!-
-
!L63
+
!E
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!L,M,V
-
!G73
+
!-
-
!T74
+
!V,I,T, L
-
!L76
+
!C,S,T, A
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!A,T,F, I
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!V
-
!L90
+
!<font color='red'>S</font>
-
!I93
+
!-
 +
!M
 +
!L,M
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Darunavir_and_ritonavir/1'>Visualize</scene>
![[Darunavir]] & [[Ritonavir]]
![[Darunavir]] & [[Ritonavir]]
-
!L10
+
!-
-
!I13
+
!I
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!<font color='red'>V</font>
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!<font color='red'>M,L</font>
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!P
-
!V82
+
!<font color='red'>V</font>
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!V
 +
!-
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Fosamprenavir_and_ritonavir/1'>Visualize</scene>
![[Fosamprenavir]] & [[Ritonavir]]
![[Fosamprenavir]] & [[Ritonavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!V
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!L,V,M
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!-
-
!I84
+
!A,F,S, T
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Indinavir_and_ritonair/1'>Visualize</scene>
![[Indinavir]] & [[Ritonavir]]
![[Indinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!<font color='red'>I,L</font>
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S,A
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!I
-
!I84
+
!<font color='red'>A,F,T</font>
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir_and_ritonavir/1'>Visualize</scene>
![[Saquinavir]] & [[Ritonavir]]
![[Saquinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!<font color='red'>V</font>
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V,L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
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Current revision

Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

Proteopedia Page Contributors and Editors (what is this?)

David Canner

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