HIV Protease Resistance

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{| class="wikitable" border="1" width="98%" style="text-align:center"
{| class="wikitable" border="1" width="98%" style="text-align:center"
|-
|-
-
! colspan="38" align="center"| Resistance Mutations
+
! colspan="40" align="center"| Resistance Mutations
|-
|-
-
!Visualize
+
!
-
!Inhibitor/Mutation Site
+
!Inhibitor/ Mutation Site
!L10
!L10
 +
!V11
!I13
!I13
!G16
!G16
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!F53
!F53
!I54
!I54
 +
!Q58
!D60
!D60
!I62
!I62
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!I93
!I93
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Ritonavir/3'>Visualize</scene>
![[Ritonavir]]
![[Ritonavir]]
!I,R,V
!I,R,V
 +
!-
!-
!-
!-
!-
Line 56: Line 59:
!I
!I
!-
!-
-
!<font color='red'>I,L</font>
+
!I,L
!-
!-
!-
!-
!-
!-
!-
!-
-
!V,L
+
!<font color='red'>V,L</font>
 +
!-
!-
!-
!-
!-
Line 71: Line 75:
!-
!-
!-
!-
-
!I
+
!<font color='red'>I</font>
-
!A,F,T,S
+
!<font color='red'>A,F,T, S</font>
!-
!-
-
!V
+
!<font color='red'>V</font>
!-
!-
!-
!-
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!-
!-
|-
|-
-
!<scene name='User:David_Canner/Sandbox_HIV/Catalytic_triad/3'>Visualize</scene>
+
!<scene name='HIV_Protease_Resistance/Indinavir/4'>Visualize</scene>
![[Indinavir]]
![[Indinavir]]
!I,R,V
!I,R,V
 +
!-
!-
!-
!-
!-
Line 94: Line 99:
!-
!-
!I
!I
-
!
+
!-
-
!I,L
+
!<font color='red'>I,L</font>
!-
!-
!-
!-
Line 101: Line 106:
!-
!-
!V
!V
 +
!-
!-
!-
!-
!-
Line 107: Line 113:
!-
!-
!V,T
!V,T
-
!S,A
+
!<font color='red'>S,A</font>
!-
!-
!-
!-
-
!I
+
!<font color='red'>I</font>
-
!A,F,T
+
!<font color='red'>A,F,T</font>
!
!
-
!V
+
!<font color='red'>V</font>
!-
!-
!-
!-
Line 120: Line 126:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir/2'>Visualize</scene>
![[Saquinavir]]
![[Saquinavir]]
!I,R,V
!I,R,V
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!-
!-
!-
!-
-
!V
+
!-
 +
!<font color='red'>V</font>
!-
!-
!-
!-
!V,L
!V,L
 +
!-
!-
!-
!-
!-
Line 146: Line 154:
!-
!-
!V,T
!V,T
-
!S
+
!<font color='red'>S</font>
!-
!-
!-
!-
-
!I
+
!<font color='red'>I</font>
!A
!A
!-
!-
Line 156: Line 164:
!-
!-
!-
!-
-
!M
+
!<font color='red'>M</font>
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Nelfinavir/1'>Visualize</scene>
![[Nelfinavir]]
![[Nelfinavir]]
-
!L10
+
!F,I
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!<font color='red'>N</font>
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!-
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!-
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!I
-
!I84
+
!A,F,T, S
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!D,S
-
!I93
+
!
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Amprenavir/1'>Visualize</scene>
![[Amprenavir]]
![[Amprenavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!V
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!L,V,M
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir/1'>Visualize</scene>
![[Atazanavir]]
![[Atazanavir]]
-
!L10
+
!I,F,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!R,M,I
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!I,F,V
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I,L,V
-
!M46
+
!-
-
!I47
+
!I
-
!G48
+
!-
-
!I50
+
!V
-
!F53
+
!<font color='red'>L</font>
-
!I54
+
!-
-
!D60
+
!L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V
-
!L76
+
!C,S,T, A
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!A
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!S
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Lopinavir_and_ritonavir/1'>Visualize</scene>
![[Lopinavir]] & [[Ritonavir]]
![[Lopinavir]] & [[Ritonavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!<font color='red'>I</font>
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!<font color='red'>V,A</font>
-
!I50
+
!-
-
!F53
+
!V
-
!I54
+
!L
-
!D60
+
!V,L,A, M,T,S
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!P
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!<font color='red'>V</font>
-
!N83
+
!-
-
!I84
+
!<font color='red'>A,F,T, S</font>
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir_and_ritonavir/1'>Visualize</scene>
![[Atazanavir]] & [[Ritonavir]]
![[Atazanavir]] & [[Ritonavir]]
-
!L10
+
!I,F,V, C
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!E
-
!L24
+
!R,M,I, T,V
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!I,F,V
-
!E35
+
!Q
-
!M36
+
!-
-
!K43
+
!I,L,V
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!V
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!L,Y
-
!D60
+
!L,V,M, T,A
-
!I62
+
!-
-
!L63
+
!E
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!L,M,V
-
!G73
+
!-
-
!T74
+
!V,I,T, L
-
!L76
+
!C,S,T, A
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!A,T,F, I
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!V
-
!L90
+
!<font color='red'>S</font>
-
!I93
+
!-
 +
!M
 +
!L,M
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Darunavir_and_ritonavir/1'>Visualize</scene>
![[Darunavir]] & [[Ritonavir]]
![[Darunavir]] & [[Ritonavir]]
-
!L10
+
!-
-
!I13
+
!I
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!<font color='red'>V</font>
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!<font color='red'>M,L</font>
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!P
-
!V82
+
!<font color='red'>V</font>
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!V
 +
!-
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Fosamprenavir_and_ritonavir/1'>Visualize</scene>
![[Fosamprenavir]] & [[Ritonavir]]
![[Fosamprenavir]] & [[Ritonavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!V
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!L,V,M
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!-
-
!I84
+
!A,F,S, T
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Indinavir_and_ritonair/1'>Visualize</scene>
![[Indinavir]] & [[Ritonavir]]
![[Indinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!<font color='red'>I,L</font>
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S,A
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!I
-
!I84
+
!<font color='red'>A,F,T</font>
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir_and_ritonavir/1'>Visualize</scene>
![[Saquinavir]] & [[Ritonavir]]
![[Saquinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!<font color='red'>V</font>
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V,L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!I
-
!I84
+
!A,F,T, S
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Tip_and_rot/1'>Visualize</scene>
![[Tipranavir]] & [[Ritonavir]]
![[Tipranavir]] & [[Ritonavir]]
-
!L10
+
!V
-
!I13
+
!-
-
!G16
+
!V
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!G
-
!K43
+
!I
-
!M46
+
!T
-
!I47
+
!L
-
!G48
+
!<font color='red'>V</font>
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!A,M,V
-
!I62
+
!<font color='red'>E<font>
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!K
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!<font color='red'>P</font>
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!<font color='red'>L,T</font>
-
!I85
+
!D
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
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!I93
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Current revision

Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

Proteopedia Page Contributors and Editors (what is this?)

David Canner

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