HIV Protease Resistance

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Current revision (10:26, 6 December 2010) (edit) (undo)
 
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{| class="wikitable" border="1" width="98%" style="text-align:center"
{| class="wikitable" border="1" width="98%" style="text-align:center"
|-
|-
-
! colspan="38" align="center"| Resistance Mutations
+
! colspan="40" align="center"| Resistance Mutations
|-
|-
-
!Visualize
+
!
-
!Inhibitor/Mutation Site
+
!Inhibitor/ Mutation Site
!L10
!L10
 +
!V11
!I13
!I13
!G16
!G16
Line 23: Line 24:
!F53
!F53
!I54
!I54
 +
!Q58
!D60
!D60
!I62
!I62
Line 42: Line 44:
!I93
!I93
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Ritonavir/3'>Visualize</scene>
![[Ritonavir]]
![[Ritonavir]]
!I,R,V
!I,R,V
 +
!-
!-
!-
!-
!-
Line 62: Line 65:
!-
!-
!<font color='red'>V,L</font>
!<font color='red'>V,L</font>
 +
!-
!-
!-
!-
!-
Line 72: Line 76:
!-
!-
!<font color='red'>I</font>
!<font color='red'>I</font>
-
!<font color='red'>A,F,T,S</font>
+
!<font color='red'>A,F,T, S</font>
!-
!-
!<font color='red'>V</font>
!<font color='red'>V</font>
Line 81: Line 85:
!-
!-
|-
|-
-
!<scene name='User:David_Canner/Sandbox_HIV/Catalytic_triad/3'>Visualize</scene>
+
!<scene name='HIV_Protease_Resistance/Indinavir/4'>Visualize</scene>
![[Indinavir]]
![[Indinavir]]
!I,R,V
!I,R,V
 +
!-
!-
!-
!-
!-
Line 101: Line 106:
!-
!-
!V
!V
 +
!-
!-
!-
!-
!-
Line 120: Line 126:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir/2'>Visualize</scene>
![[Saquinavir]]
![[Saquinavir]]
!I,R,V
!I,R,V
 +
!-
!-
!-
!-
!-
Line 140: Line 147:
!-
!-
!V,L
!V,L
 +
!-
!-
!-
!-
!-
Line 159: Line 167:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Nelfinavir/1'>Visualize</scene>
![[Nelfinavir]]
![[Nelfinavir]]
!F,I
!F,I
 +
!-
!-
!-
!-
!-
Line 174: Line 183:
!-
!-
!I,L
!I,L
 +
!-
!-
!-
!-
!-
Line 189: Line 199:
!-
!-
!I
!I
-
!A,F,T,S
+
!A,F,T, S
!-
!-
!V
!V
Line 198: Line 208:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Amprenavir/1'>Visualize</scene>
![[Amprenavir]]
![[Amprenavir]]
-
!F,I,R,V
+
!F,I,R, V
 +
!-
!-
!-
!-
!-
Line 218: Line 229:
!-
!-
!L,V,M
!L,V,M
 +
!-
!-
!-
!-
!-
Line 237: Line 249:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir/1'>Visualize</scene>
![[Atazanavir]]
![[Atazanavir]]
!I,F,V
!I,F,V
 +
!-
!-
!-
!-
!-
Line 257: Line 270:
!-
!-
!L
!L
 +
!-
!-
!-
!-
!-
Line 263: Line 277:
!-
!-
!V
!V
-
!C,S,T,A
+
!C,S,T, A
!-
!-
!-
!-
Line 276: Line 290:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Lopinavir_and_ritonavir/1'>Visualize</scene>
![[Lopinavir]] & [[Ritonavir]]
![[Lopinavir]] & [[Ritonavir]]
-
!F,I,R,V
+
!F,I,R, V
 +
!-
!-
!-
!-
!-
Line 295: Line 310:
!V
!V
!L
!L
-
!V,L,A,M,T,S
+
!V,L,A, M,T,S
 +
!-
!-
!-
!-
!-
Line 306: Line 322:
!<font color='red'>V</font>
!<font color='red'>V</font>
!-
!-
-
!<font color='red'>A,F,T,S</font>
+
!<font color='red'>A,F,T, S</font>
!-
!-
!V
!V
Line 315: Line 331:
!
!
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir_and_ritonavir/1'>Visualize</scene>
![[Atazanavir]] & [[Ritonavir]]
![[Atazanavir]] & [[Ritonavir]]
-
!L10
+
!I,F,V, C
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!E
-
!L24
+
!R,M,I, T,V
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!I,F,V
-
!E35
+
!Q
-
!M36
+
!-
-
!K43
+
!I,L,V
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!-
-
!I50
+
!V
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!L,Y
-
!D60
+
!L,V,M, T,A
-
!I62
+
!-
-
!L63
+
!E
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!L,M,V
-
!G73
+
!-
-
!T74
+
!V,I,T, L
-
!L76
+
!C,S,T, A
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!A,T,F, I
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!V
-
!L90
+
!<font color='red'>S</font>
-
!I93
+
!-
 +
!M
 +
!L,M
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Darunavir_and_ritonavir/1'>Visualize</scene>
![[Darunavir]] & [[Ritonavir]]
![[Darunavir]] & [[Ritonavir]]
-
!L10
+
!-
-
!I13
+
!I
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!<font color='red'>V</font>
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!<font color='red'>M,L</font>
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!P
-
!V82
+
!<font color='red'>V</font>
-
!N83
+
!-
-
!I84
+
!-
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!V
 +
!-
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Fosamprenavir_and_ritonavir/1'>Visualize</scene>
![[Fosamprenavir]] & [[Ritonavir]]
![[Fosamprenavir]] & [[Ritonavir]]
-
!L10
+
!F,I,R, V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!I,L
-
!G48
+
!V
-
!I50
+
!-
-
!F53
+
!<font color='red'>V</font>
-
!I54
+
!-
-
!D60
+
!L,V,M
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!-
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!-
-
!I84
+
!A,F,S, T
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Indinavir_and_ritonair/1'>Visualize</scene>
![[Indinavir]] & [[Ritonavir]]
![[Indinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!I
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!I
-
!M46
+
!-
-
!I47
+
!<font color='red'>I,L</font>
-
!G48
+
!-
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S,A
-
!V77
+
!-
-
!V82
+
!V
-
!N83
+
!I
-
!I84
+
!<font color='red'>A,F,T</font>
-
!I85
+
!-
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir_and_ritonavir/1'>Visualize</scene>
![[Saquinavir]] & [[Ritonavir]]
![[Saquinavir]] & [[Ritonavir]]
-
!L10
+
!I,R,V
-
!I13
+
!-
-
!G16
+
!-
-
!K20
+
!-
-
!L24
+
!-
-
!D30
+
!I
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!-
-
!E35
+
!-
-
!M36
+
!-
-
!K43
+
!-
-
!M46
+
!-
-
!I47
+
!-
-
!G48
+
!-
-
!I50
+
!<font color='red'>V</font>
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!V,L
-
!I62
+
!-
-
!L63
+
!-
-
!I64
+
!V
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!-
-
!T74
+
!V,T
-
!L76
+
!S
-
!V77
+
!-
-
!V82
+
!-
-
!N83
+
!I
-
!I84
+
!A,F,T, S
-
!I85
+
!-
-
!N88
+
!V
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!<font color='red'>M</font>
 +
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Tip_and_rot/1'>Visualize</scene>
![[Tipranavir]] & [[Ritonavir]]
![[Tipranavir]] & [[Ritonavir]]
-
!L10
+
!V
-
!I13
+
!-
-
!G16
+
!V
-
!K20
+
!-
-
!L24
+
!M,R
-
!D30
+
!-
-
!V32
+
!-
-
!L33
+
!-
-
!E34
+
!F
-
!E35
+
!-
-
!M36
+
!G
-
!K43
+
!I
-
!M46
+
!T
-
!I47
+
!L
-
!G48
+
!<font color='red'>V</font>
-
!I50
+
!-
-
!F53
+
!-
-
!I54
+
!-
-
!D60
+
!A,M,V
-
!I62
+
!<font color='red'>E<font>
-
!L63
+
!-
-
!I64
+
!-
-
!H69
+
!-
-
!A71
+
!-
-
!G73
+
!K
-
!T74
+
!-
-
!L76
+
!-
-
!V77
+
!<font color='red'>P</font>
-
!V82
+
!-
-
!N83
+
!-
-
!I84
+
!<font color='red'>L,T</font>
-
!I85
+
!D
-
!N88
+
!<font color='red'>V</font>
-
!L89
+
!-
-
!L90
+
!-
-
!I93
+
!-
 +
!M
 +
!-
|-
|-
|}
|}

Current revision

Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

Proteopedia Page Contributors and Editors (what is this?)

David Canner

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