This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


HIV Protease Resistance

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:26, 6 December 2010) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
{| class="wikitable" border="1" width="98%" style="text-align:center"
{| class="wikitable" border="1" width="98%" style="text-align:center"
|-
|-
-
! colspan="39" align="center"| Resistance Mutations
+
! colspan="40" align="center"| Resistance Mutations
|-
|-
-
!Visualize
+
!
-
!Inhibitor/Mutation Site
+
!Inhibitor/ Mutation Site
!L10
!L10
!V11
!V11
Line 24: Line 24:
!F53
!F53
!I54
!I54
 +
!Q58
!D60
!D60
!I62
!I62
Line 43: Line 44:
!I93
!I93
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Ritonavir/3'>Visualize</scene>
![[Ritonavir]]
![[Ritonavir]]
!I,R,V
!I,R,V
Line 64: Line 65:
!-
!-
!<font color='red'>V,L</font>
!<font color='red'>V,L</font>
-
!QQQ
+
!-
!-
!-
!-
!-
Line 75: Line 76:
!-
!-
!<font color='red'>I</font>
!<font color='red'>I</font>
-
!<font color='red'>A,F,T,S</font>
+
!<font color='red'>A,F,T, S</font>
!-
!-
!<font color='red'>V</font>
!<font color='red'>V</font>
Line 84: Line 85:
!-
!-
|-
|-
-
!<scene name='User:David_Canner/Sandbox_HIV/Catalytic_triad/3'>Visualize</scene>
+
!<scene name='HIV_Protease_Resistance/Indinavir/4'>Visualize</scene>
![[Indinavir]]
![[Indinavir]]
!I,R,V
!I,R,V
Line 105: Line 106:
!-
!-
!V
!V
-
!QQQ
+
!-
!-
!-
!-
!-
Line 125: Line 126:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir/2'>Visualize</scene>
![[Saquinavir]]
![[Saquinavir]]
!I,R,V
!I,R,V
Line 146: Line 147:
!-
!-
!V,L
!V,L
-
!QQQ
+
!-
!-
!-
!-
!-
Line 166: Line 167:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Nelfinavir/1'>Visualize</scene>
![[Nelfinavir]]
![[Nelfinavir]]
!F,I
!F,I
Line 187: Line 188:
!-
!-
!-
!-
-
!QQQ
+
!-
!-
!-
!-
!-
Line 198: Line 199:
!-
!-
!I
!I
-
!A,F,T,S
+
!A,F,T, S
!-
!-
!V
!V
Line 207: Line 208:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Amprenavir/1'>Visualize</scene>
![[Amprenavir]]
![[Amprenavir]]
-
!F,I,R,V
+
!F,I,R, V
!-
!-
!-
!-
Line 228: Line 229:
!-
!-
!L,V,M
!L,V,M
-
!QQQ
+
!-
!-
!-
!-
!-
Line 248: Line 249:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir/1'>Visualize</scene>
![[Atazanavir]]
![[Atazanavir]]
!I,F,V
!I,F,V
Line 269: Line 270:
!-
!-
!L
!L
-
!QQQ
+
!-
!-
!-
!-
!-
Line 276: Line 277:
!-
!-
!V
!V
-
!C,S,T,A
+
!C,S,T, A
!-
!-
!-
!-
Line 289: Line 290:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Lopinavir_and_ritonavir/1'>Visualize</scene>
![[Lopinavir]] & [[Ritonavir]]
![[Lopinavir]] & [[Ritonavir]]
-
!F,I,R,V
+
!F,I,R, V
!-
!-
!-
!-
Line 309: Line 310:
!V
!V
!L
!L
-
!V,L,A,M,T,S
+
!V,L,A, M,T,S
-
!QQQ
+
!-
!-
!-
!-
!-
Line 321: Line 322:
!<font color='red'>V</font>
!<font color='red'>V</font>
!-
!-
-
!<font color='red'>A,F,T,S</font>
+
!<font color='red'>A,F,T, S</font>
!-
!-
!V
!V
Line 330: Line 331:
!
!
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Atazanavir_and_ritonavir/1'>Visualize</scene>
![[Atazanavir]] & [[Ritonavir]]
![[Atazanavir]] & [[Ritonavir]]
-
!I,F,V,C
+
!I,F,V, C
!-
!-
!-
!-
!E
!E
-
!R,M,I,T,V
+
!R,M,I, T,V
!I
!I
!-
!-
Line 350: Line 351:
!<font color='red'>V</font>
!<font color='red'>V</font>
!L,Y
!L,Y
-
!L,V,M,T,A
+
!L,V,M, T,A
-
!QQQ
+
!-
!E
!E
!V
!V
Line 357: Line 358:
!L,M,V
!L,M,V
!-
!-
-
!V,I,T,L
+
!V,I,T, L
-
!C,S,T,A
+
!C,S,T, A
!-
!-
!-
!-
!-
!-
-
!A,T,F,I
+
!A,T,F, I
!-
!-
!<font color='red'>V</font>
!<font color='red'>V</font>
Line 371: Line 372:
!L,M
!L,M
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Darunavir_and_ritonavir/1'>Visualize</scene>
![[Darunavir]] & [[Ritonavir]]
![[Darunavir]] & [[Ritonavir]]
!-
!-
Line 392: Line 393:
!-
!-
!<font color='red'>M,L</font>
!<font color='red'>M,L</font>
-
!QQQ
+
!-
!-
!-
!-
!-
Line 412: Line 413:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Fosamprenavir_and_ritonavir/1'>Visualize</scene>
![[Fosamprenavir]] & [[Ritonavir]]
![[Fosamprenavir]] & [[Ritonavir]]
-
!F,I,R,V
+
!F,I,R, V
!-
!-
!-
!-
Line 433: Line 434:
!-
!-
!L,V,M
!L,V,M
-
!QQQ
+
!-
!-
!-
!-
!-
Line 444: Line 445:
!V
!V
!-
!-
-
!A,F,S,T
+
!A,F,S, T
!-
!-
!<font color='red'>V</font>
!<font color='red'>V</font>
Line 453: Line 454:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Indinavir_and_ritonair/1'>Visualize</scene>
![[Indinavir]] & [[Ritonavir]]
![[Indinavir]] & [[Ritonavir]]
!I,R,V
!I,R,V
Line 474: Line 475:
!-
!-
!V
!V
-
!QQQ
+
!-
!-
!-
!-
!-
Line 494: Line 495:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Saquinavir_and_ritonavir/1'>Visualize</scene>
![[Saquinavir]] & [[Ritonavir]]
![[Saquinavir]] & [[Ritonavir]]
!I,R,V
!I,R,V
Line 515: Line 516:
!-
!-
!V,L
!V,L
-
!QQQ
+
!-
!-
!-
!V
!V
Line 526: Line 527:
!-
!-
!I
!I
-
!A,F,T,S
+
!A,F,T, S
!-
!-
!V
!V
Line 535: Line 536:
!-
!-
|-
|-
-
!Visualize
+
!<scene name='HIV_Protease_Resistance/Tip_and_rot/1'>Visualize</scene>
![[Tipranavir]] & [[Ritonavir]]
![[Tipranavir]] & [[Ritonavir]]
!V
!V

Current revision

Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

Proteopedia Page Contributors and Editors (what is this?)

David Canner

Retrieved from "http://52.214.119.220/wiki/index.php/HIV_Protease_Resistance"
Personal tools